PLEASE NOTE:

MyNews24 is a user-generated section of News24.com. The stories here come from users.

 
Mawethu Bilibana
 
Comments: 2
Article views: 6
 
 
Latest Badges:

 
View all Mawethu Bilibana's badges.
 

Immune gene that control HI-Virus

10 December 2012, 09:22

A study published in the journal Nature Immunology reveal a gene that is essential for embryo survival could also be the key to treating chronic infections such as HIV. Genes are the working subunits of DNA, where DNA stand for Deoxyribonucleic acid, a chemical information database that carries the complete set of instructions for the cell as to the nature of the proteins produced by it, its life span, maturity, function and death. Therefore, each gene contains a particular set of instructions, usually coding for a particular protein or for a particular function. The gene, called Arih2 produce a protein that is fundamental to the function of the immune system, making critical decisions about whether to switch on the immune response to an infection.

Researchers said that Arih2 is found in dendritic cells, the sentinels of the immune system that play an essential role in raising the alarm about the presence of foreign invaders in the body.

But while our immune system works well against many infections, chronic overwhelming infections such as HIV ‘exhaust’ and switch off the immune system, similar to autoimmune diseases such as rheumatoid arthritis and sepsis.

Indeed, during evolution, some organisms have evolved ways of exhausting our immune system to the point where the immune system just switches off, and this is what happens in HIV, hepatitis B, and tuberculosis. These organisms counter the immune response – exhausting T cells which are stimulated over and over again by the infection and becoming exhausted or paralyzed.

In the study, mice that were deficient in ARIH2 died before birth (embryonic lethal). Some of the mice with a mixed genetic background survived to birth but succumbed to an aggressive multi-organ inflammatory response.

Hence, the researchers are now looking at the effect on the immune response of switching off Arih2 for short periods of time during chronic infections.

This discovery has significant implications for manipulating the immune response to infections and suppressing chronic inflammation or autoimmunity because we can target this gene to try to push immune responses in one or other direction – either promoting it or suppressing it.

Disclaimer: All articles and letters published on MyNews24 have been independently written by members of News24's community. The views of users published on News24 are therefore their own and do not necessarily represent the views of News24. News24 editors also reserve the right to edit or delete any and all comments received.

 

24.com publishes all comments posted on articles provided that they adhere to our Comments Policy. Should you wish to report a comment for editorial review, please do so by clicking the 'Report Comment' button to the right of each comment.

Comment on this story
2 comments
Comments have been closed for this article.

Read more from our Users

Submitted by
Michael Mondli Hlophe
I worry about coalition governmen...

We can only speculate about the future results of coalition governments in South Africa. We can however agree that with coalitions, come challenges. Read more...

0 comments 268 views
Submitted by
Deon van Wyk
Questions about level 5 water res...

The monthly water reading varies monthly for a period between 27 to 35 days and after the holidays even 40 days. In these cases the monthly water usage will be more than 20kl per month. Will you be fined?  Read more...

0 comments 435 views
Submitted by
Amir Abdulazeez
Messi vs Ronaldo: a philosophical...

Cristiano Ronaldo will most likely settle as the 3rd all-time greatest player. In Messi’s case, he may rank worse than 3rd in many critical categories. Read more...

0 comments 271 views
Submitted by
Adorn Keketso
Africans must unite to find water...

African (and South African) leaders must realise that we are trapped in a vicious circle of foreign aids and that our deepening food and water crisis is the opportunity for the western power to take advantage of our sovereignty.  Read more...

0 comments 419 views
Submitted by
Sibonginkosi Mabika
A political storm is being contri...

Political uncertainty puts the citizens of South Africa in darkness preparing themselves for country’s biggest political storm.  Read more...

0 comments 727 views
Submitted by
Nkosenhle Sibisi
Dlamini-Zuma to be sworn in as AN...

I honestly think that it is time to stop scepticism as South Africans and give our female candidates a chance to lead and save our beautiful country, South Africa. Read more...

0 comments 822 views
 

services

E-mail Alerts The latest headlines in your inbox

RSS feeds News delivered really simply.

Mobile News24 on your mobile or PDA

E-mail Newsletters You choose what you want

News24 on Android Get the latest from News24 on your Android device.

SMS Alerts Get breaking news stories via SMS.

TV Get us in your home, on your television.

 
Interactive Advertising Bureau
 
© 2017 24.com. All rights reserved.
There are new stories on the homepage. Click here to see them.
 
English
Afrikaans
isiZulu

Hello 

Create Profile

Creating your profile will enable you to submit photos and stories to get published on News24.


Please provide a username for your profile page:

This username must be unique, cannot be edited and will be used in the URL to your profile page across the entire 24.com network.

Settings

Location Settings

News24 allows you to edit the display of certain components based on a location. If you wish to personalise the page based on your preferences, please select a location for each component and click "Submit" in order for the changes to take affect.




Facebook Sign-In

Hi News addict,

Join the News24 Community to be involved in breaking the news.

Log in with Facebook to comment and personalise news, weather and listings.