PLEASE NOTE:

MyNews24 is a user-generated section of News24.com. The stories here come from users.

 
Mawethu Bilibana
 
Comments: 2
Article views: 317
 
 
Latest Badges:

 
View all Mawethu Bilibana's badges.
 

Immune gene that control HI-Virus

10 December 2012, 09:22

A study published in the journal Nature Immunology reveal a gene that is essential for embryo survival could also be the key to treating chronic infections such as HIV. Genes are the working subunits of DNA, where DNA stand for Deoxyribonucleic acid, a chemical information database that carries the complete set of instructions for the cell as to the nature of the proteins produced by it, its life span, maturity, function and death. Therefore, each gene contains a particular set of instructions, usually coding for a particular protein or for a particular function. The gene, called Arih2 produce a protein that is fundamental to the function of the immune system, making critical decisions about whether to switch on the immune response to an infection.

Researchers said that Arih2 is found in dendritic cells, the sentinels of the immune system that play an essential role in raising the alarm about the presence of foreign invaders in the body.

But while our immune system works well against many infections, chronic overwhelming infections such as HIV ‘exhaust’ and switch off the immune system, similar to autoimmune diseases such as rheumatoid arthritis and sepsis.

Indeed, during evolution, some organisms have evolved ways of exhausting our immune system to the point where the immune system just switches off, and this is what happens in HIV, hepatitis B, and tuberculosis. These organisms counter the immune response – exhausting T cells which are stimulated over and over again by the infection and becoming exhausted or paralyzed.

In the study, mice that were deficient in ARIH2 died before birth (embryonic lethal). Some of the mice with a mixed genetic background survived to birth but succumbed to an aggressive multi-organ inflammatory response.

Hence, the researchers are now looking at the effect on the immune response of switching off Arih2 for short periods of time during chronic infections.

This discovery has significant implications for manipulating the immune response to infections and suppressing chronic inflammation or autoimmunity because we can target this gene to try to push immune responses in one or other direction – either promoting it or suppressing it.

Disclaimer: All articles and letters published on MyNews24 have been independently written by members of News24's community. The views of users published on News24 are therefore their own and do not necessarily represent the views of News24. News24 editors also reserve the right to edit or delete any and all comments received.
 

Read News24’s Comments Policy

24.com publishes all comments posted on articles provided that they adhere to our Comments Policy. Should you wish to report a comment for editorial review, please do so by clicking the 'Report Comment' button to the right of each comment.

Comment on this story
2 comments
Add your comment
Comment 0 characters remaining

Read more from our Users

Submitted by
Bolsheviks Partysa
Irregular, unauthorised and waste...

It seems to have become the norm rather than the exception for any government department to have spent taxpayer’s money in a manner in which it can’t account for the what and who was paid. Read more...

0 comments 0 views
Submitted by
ProJusticio
South Africa is in very grave dan...

If the ANC and the EFF get a two-thirds majority needed to tear up the Constitution that will be the beginning of the end for SA. Read more...

22 comments 1279 views
Submitted by
Dr. G. Dharmaraja
NUMSA launching the left party

NUMSA has been expected to fulfill the longstanding dream of South Africa’s toiling masses: a new movement for socialism.  Read more...

7 comments 425 views
Submitted by
Trevor McArthur
In defence of the opposition to s...

To the security cluster ministers: It is not the EFF that is posing a threat to national security but yourselves! Read more...

5 comments 261 views
Submitted by
Inspired Parenting
Parenting Leaders

A new law is being drafted in SA to stop parents smacking their children. This is extremely good news. Read more...

20 comments 299 views
Submitted by
JohnDough
Denied access to your children?

I understand that each and every divorce case is different, but the denial of access and withholding of maintenance are way too often used as weapons.  Read more...

7 comments 374 views

Jobs in Cape Town [change area]

Jobs in Western Cape region

Audit Manager

Western Cape
SET Recruitment Consultants
R450 000 - R550 000 Per Year

Call Centre Agents

Cape Town
Teleresources Cape Town

Analyst Developer

Cape Town CBD
Mpumalanga Personnel & Training Consultants

Property [change area]

Travel - Look, Book, Go!

Magical Massinga

Spend 5 nights at the gorgeous Massinga Beach Lodge in Mozambique and only pay for 4 from R13 220 per person sharing. Includes return flights, accommodation, transfers and romantic turndown. Book now!

Kalahari.com - shop online today

Up to 40% off fashion accessories

Save up to 40% on selected handbags, purses, watches, jewellery and more. Offer valid while stocks last. Shop now!

Save up to R2000 on top electronics

Get every day mind bowing savings on top electronics. Offer valid while stocks last. Shop now!

As seen on TV - New book releases at only R199 each

Get mind blowing book savings on new titles. Offer valid while stocks last. Shop now!

Save up to 50% on Women’s month treats!

Celebrate the awesome women in your life with awesome treats like beauty products, fashion accessories, bestselling books, electronics and more. Offer valid while stocks last. Shop now!

Up to 60% off - clearance sale!

Save up to 60% on appliances, books, electronics, toys, movies and more. Offer valid while stocks last. Shop now!

OLX Free Classifieds [change area]

Samsung Galaxy s4

Mobile, Cell Phones in South Africa, Western Cape, Cape Town. Date October 24

Best bargain in big bay

Real Estate, Houses - Apartments for Sale in South Africa, Western Cape, Cape Town. Date October 25

VW Golf 6, 1.6 Trendline (Excellent condition)

Vehicles, Cars in South Africa, Western Cape, Cape Town. Date October 25

 

services

E-mail Alerts The latest headlines in your inbox

RSS feeds News delivered really simply.

Mobile News24 on your mobile or PDA

E-mail Newsletters You choose what you want

News24 on your iPhone Get News24 headlines on your iPhone.

SMS Alerts Get breaking news stories via SMS.

Blogs Your opinion on you, me and everyone.

Calais Website keywords automated by OpenCalais.

 
Interactive Advertising Bureau
 
© 2014 24.com. All rights reserved.
There are new stories on the homepage. Click here to see them.
 
English
Afrikaans
isiZulu

Hello 

Create Profile

Creating your profile will enable you to submit photos and stories to get published on News24.


Please provide a username for your profile page:

This username must be unique, cannot be edited and will be used in the URL to your profile page across the entire 24.com network.

Settings

Location Settings

News24 allows you to edit the display of certain components based on a location. If you wish to personalise the page based on your preferences, please select a location for each component and click "Submit" in order for the changes to take affect.








Facebook Sign-In

Hi News addict,

Join the News24 Community to be involved in breaking the news.

Log in with Facebook to comment and personalise news, weather and listings.