New treatment for food allergies
2008-12-01 10:41
London - A European team of scientists are embarking on new research to develop food allergy treatments.
Classical treatment with allergen-specific immunotherapy, where a patient received monthly injections with an allergen extract for three to five years, is effective but dangerous due to anaphylactic side-effects.
In the Fast project, scientists will use modified variants of allergic proteins that are hypoallergenic and therefore safer.
The proteins will be purified to increase effectiveness and dosage control easier.
"Food allergy affects around 10 million EU citizens and there is no cure," says Dr Clare Mills of the Institute of Food Research, a lead partner in the Food Allergy Specific Therapy (Fast) research project.
Anaphylaxis
"All people with food allergy can do is avoid the foods to which they are allergic. The threat of severe anaphylaxis has a great impact on their quality of life."
Attempted treatment with allergen-specific immunotherapy, where a patient received monthly injections with an allergen extract for three to five years, failed because it could cause anaphylaxis as a side effect.
Anaphylaxis is a severe allergic reaction involving the whole body, often within minutes of exposure to the allergen.
Peanut allergy is the most widely known cause, but other causes of anaphylaxis include other foods, insect stings, latex and drugs. If untreated in time it can be fatal.
Ninety percent of all food allergies are caused by about 10 foods.
Allergies to fish and fruit are among the most common in Europe.
Parvalbumin
In fish allergy the protein responsible is parvalbumin and in fruit it is lipid transfer protein (LTP).
Modified hypo-allergenic versions of these proteins will be produced at tested as potential treatments.
"We are hoping for a cure that will allow people to eat fish or fruit again," says Dr Ronald van Ree from the Academic Medical Centre at the University of Amsterdam.
"But a significant reduction of sensitivity would already be a great step forwards.
"The risk of unintentional exposure due to cross-contamination of foods, or while eating in restaurants or at parties, will decrease. This will take away lot of the anxiety that has a negative impact on the quality of life of food allergy sufferers."
Source: Institute of Food Research, UK