Scientists closer to Ebola drug

2010-08-22 22:43

Paris - US scientists said on Sunday they had cleared a key hurdle in the quest for a drug to treat Ebola, a notorious African virus and feared future weapon of bioterrorism.

A treatment administered to rhesus monkeys within an hour of being infected by the deadliest strain of Ebola was 60% effective, and a companion drug was 100% effective in shielding cynomolgus monkeys against Ebola's cousin, the Marburg virus.

After studying the findings, the US Food and Drug Administration (FDA) has given the green light for trials on a small group of human volunteers, they said.

Ebola and Marburg are part of a family of so-called filoviruses, which cause haemorrhagic fever - a disease with mortality rates of up to 90% where, in some cases, the patient bleeds to death.

The drugs are in a class of compound called PMO, for phosphorodiamidate morpholino oligomers. They are designed to hamper the virus' replication in cells, thus buying time for the immune system to mount a response and crush the invader.

The research, appearing online in the journal Nature Medicine, was conducted by the US Army Medical Research Institute of Infectious Diseases in collaboration with a Washington-based biotech firm, AVI BioPharma.

The Pentagon pumped funding into research for a vaccine and treatment for Ebola-type viruses in the wake of the September 9 2001 terror attacks on the United States.

Filoviruses are on the list of pathogens such as anthrax that are considered tempting sources for biological warfare or terrorism.

An important step in combating Ebola was announced in May this year, again using tests on lab monkeys but involving a somewhat different technique to disrupt viral replication.

A team at the US National Emerging Diseases Laboratory Institute at Boston University Medical School designed drugs with small interfering RNAs, or siRNAs, which hamstring reproductive enzymes.

Despite this progress, a long road lies ahead before any treatment is licensed for humans, experts say.

Testing a prototype drug is a three-phase process that starts with a tiny group of volunteers, where it is initially assessed for safety, and then broadens out to successively bigger groups, where effectiveness becomes a parallel question.

According to the UN's World Health Organisation (WHO), about 1 850 cases of Ebola, with some 1 200 deaths, have occurred since 1976.

The virus has a natural reservoir in several species of African fruit bat.

Gorillas and other non-human primates are also susceptible to the disease.