US breakthrough in live cancer cells

2011-12-19 18:31

Washington - US researchers said on Monday they have discovered how to keep tumour cells alive in the lab, generating buzz in the scientific community about a potential breakthrough that could transform cancer treatment.

Until now, scientists have been unable to make cancer cells thrive for very long in the laboratory in a condition that resembles the way they look and act in the body. Doctors have largely relied on biopsied tissue that is frozen or set in wax to diagnose and recommend treatment.

The advance has sparked new hope that someday doctors may be able to test a host of cancer-killing drugs on a person's own tumour cells in the lab, before returning to the patient with a therapy that is likely to be a good match.

"This would really be the ultimate in personalised medicine," said lead author Richard Schlegel, chair of the department of pathology at Georgetown University's Lombardi Comprehensive Cancer Centre.

"The therapies would be exactly from their tissues. We would get normal tissue and tumour tissue from a particular patient and specifically match up their therapies," Schlegel said.

"We are really excited about the possibilities of testing what we can do with this."

Simple method

The method, described in the online edition of the American Journal of Pathology, borrows on a simple method used in stem cell research, experts said.

Lung, breast, prostate and colon cancers were kept alive for up to two years using the technique, which combines fibroblast feeder cells to keep cells alive and a Rho kinase (Rock) inhibitor that allows them to reproduce.

When treated with the duo, both cancer and normal cells reverted to a "stem-like state", Schlegel said, allowing researchers to compare the living cells directly for the first time.

The two elements have previously been used separately in stem cell research, according to Yale University pathology professor David Rimm, who wrote a commentary that accompanies the article.

"No individual technique was new, as far as I know. It was in some sense a very clever combination that led to this success," Rimm said.

Rimm cautioned that more labs need to show they can do it too, and that attempts to try different therapies to kill the cancer cells are just "speculation" now, but described the initial results as "pretty compelling".

"One of my senior scientists went down to Georgetown for a week and she got it to work. She got pancreatic cells to work, which is impossible. Even they were having trouble with that one," he said.

"So that just further served to stoke my enthusiasm, rather than generate scepticism."

Cause of death

If other scientists can replicate the technique - and three university labs in the US are already working on it - the advance could herald a long-awaited transformation in the way cancer cells are studied.

The study was published after two years of research in collaboration with National Institutes of Health scientists and was funded by the NIH, the Department of Defence, Georgetown University and the National Cancer Institute.

"A tumour from one patient is different from a cancer from another patient, even though they appear to be the same under a pathologist's microscope, and really that is one important reason why so many clinical trials fail," said Marc Symons, investigator at the Centre for Oncology and Cell Biology at The Feinstein Institute for Medical Research in Manhasset, New York.

"I think it is fair to say this may revolutionise the way we think of cancer treatment," added Symons, who was not involved in the study.

Cancer is the leading cause of death in the world, killing 7.6 million people in 2008 according to the latest data from the World Health Organisation.

Mark Friedman, who works in the department of pathology at St Luke's Roosevelt Hospital, said the real gain for patients could be reducing the harmful effects of chemotherapy that may not be suited for various tumours.

"This would be a tremendous benefit for the patient because you would be minimising toxicity while maximising the benefit of the treatment," said Friedman, who was not part of the study.

Karen Anderson, of the Biodesign Institute at Arizona State University, was one of the scientists who recently completed training in the method at Georgetown. She said the process took three days to learn.

"It is actually surprisingly straightforward... I am optimistic about it but we have to confirm whether or not the cells that are growing are really going to be the things we want to be able to study," she said.

"But I think it is pretty exciting."

Read more on:    cancer  |  research
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