Bio-engineered rat kidneys give hope

2013-04-14 22:12
This photo shows the presence of a rat trapped in a restrainer elicits focused activity from his cage mate, leading eventually to door-opening and consequent liberation of the trapped rat. (Science, AP)

This photo shows the presence of a rat trapped in a restrainer elicits focused activity from his cage mate, leading eventually to door-opening and consequent liberation of the trapped rat. (Science, AP)

Multimedia   ·   User Galleries   ·   News in Pictures Send us your pictures  ·  Send us your stories

Paris - Researchers in the United States on Sunday said they had bio-engineered a kidney and transplanted it into rats, marking a step forward in a quest to help patients suffering from kidney failure.

The prototype proves that a "bio-kidney" can work, emulating breakthroughs elsewhere to build replacement structures for livers, hearts and lungs, they said.

Described in the journal Nature Medicine, the work entailed taking a rat kidney and stripping out its living cells using a detergent solution, leaving behind a shell made of collagen.

The next step was to repopulate this empty structure with living cells, comprising human endothelial cells, which line the walls of blood vessels in the kidney, and kidney cells taken from newborn rats.

The trick was then to "seed" these cells in the correct part of the kidney, using a muscle duct called the ureter as a tube.

The team transplanted the organ into living rats from which a kidney had been removed.

The new kidney started filtering blood and producing urine through the ureter as soon as the bloody supply was restored, and there was no evidence of bleeding or clots.

Further work is needed to fine-tune the cell types to improve organ function, and many hurdles must be overcome before any tests on humans can go ahead, the scientists cautioned.

The researchers stripped cells from pig and human kidneys to test the first phase of the procedure on these organs, but have not taken this further for now.

Harald Ott of the Massachusetts General Hospital Centre for Regenerative Medicine said the goal was to help the millions of people with kidney failure whose lives are crimped by dialysis.

"If this technology can be scaled to human-sized grafts, patients suffering from renal failure who are currently waiting for donor kidneys or who are not transplant candidates could theoretically receive new organs derived from their own cells" to prevent rejection by the immune system, he said.

- SAPA
Read more on:    nature medicine  |  france  |  health  |  research
NEXT ON NEWS24X
SHARE:

Read News24’s Comments Policy

24.com publishes all comments posted on articles provided that they adhere to our Comments Policy. Should you wish to report a comment for editorial review, please do so by clicking the 'Report Comment' button to the right of each comment.

Comment on this story
12 comments
Add your comment
Comment 0 characters remaining
 

Inside News24

 
/News
 

How to make this a sensual, sexy summer!

Summer is the perfect time for rekindling cooling passions and for shedding your inhibitions as well as your clothes…

 
 

I love summer.24

This is what South Africans Googled in 2014!
This hilarious song is your new holiday anthem
The world's least visited destination is breathtaking!
LOL treadmill fail!

Jobs in Cape Town [change area]

Property [change area]

Travel - Look, Book, Go!

Kalahari.com - shop online today

2DAYS ONLY – 30% off Appliances

Coffee makers, blenders, fans, juicers and more. T&Cs apply. Shop now!

2 DAYS ONLY – 40% off books

Get 40% off when you buy 2 books. For two days only! T&Cs apply. Buy now!

Up to 50% off on outdoor gear

Save on chairs, blankets, cooler bags, umbrellas and more. Shop now!

Save on Samsung

Cameras, mobile phones, TVs, Tablets and more. While stocks last. Shop now!

Grand Theft Auto 5

Now available on PS4, Xbox One and PC from R649. Buy now!

OLX Free Classifieds [change area]

Samsung Galaxy s4

Mobile, Cell Phones in South Africa, Western Cape, Cape Town. Date October 24

Best bargain in big bay

Real Estate, Houses - Apartments for Sale in South Africa, Western Cape, Cape Town. Date October 25

VW Golf 6, 1.6 Trendline (Excellent condition)

Vehicles, Cars in South Africa, Western Cape, Cape Town. Date October 25

Horoscopes
Aquarius
Aquarius

You may be emotionally defensive or reserved today. You need to step up today as there may be extra responsibilities to deal with....read more

There are new stories on the homepage. Click here to see them.
 
English
Afrikaans
isiZulu

Hello 

Create Profile

Creating your profile will enable you to submit photos and stories to get published on News24.


Please provide a username for your profile page:

This username must be unique, cannot be edited and will be used in the URL to your profile page across the entire 24.com network.

Settings

Location Settings

News24 allows you to edit the display of certain components based on a location. If you wish to personalise the page based on your preferences, please select a location for each component and click "Submit" in order for the changes to take affect.








Facebook Sign-In

Hi News addict,

Join the News24 Community to be involved in breaking the news.

Log in with Facebook to comment and personalise news, weather and listings.