Trojan horse cells kill cancer
2009-06-28 22:10
Sydney - Australian scientists have developed a "Trojan horse" therapy to combat cancer, using a bacterially-derived nano cell to penetrate and disarm the cancer cell before a second nano cell kills it with chemotherapy drugs.
The therapy has the potential to directly target cancer cells with chemotherapy, rather than the current treatment that sees chemotherapy drugs injected into a cancer patient and attacking both cancer and healthy cells.
Sydney scientists Dr Jennifer MacDiarmid and Dr Himanshu Brahmbhatt, who formed EnGenelC Pty Ltd in 2001, said they had achieved 100% survival in mice with human cancer cells by using the "Trojan horse" therapy in the past two years.
The scientists plan to start human clinical trials in the coming months. Human trials of the cell delivery system will start soon at the Peter MacCullum Cancer Centre at the Royal Melbourne Hospital and The Austin at the University of Melbourne.
Production of proteins
The therapy, published in the latest Nature Biotechnology journal, sees mini-cells called EDVs (EnGenelC Delivery Vehicle) attach and enter the cancer cell.
The first wave of mini-cells release ribonucleic acid molecules, called siRNA, which switch off the production of proteins that make the cancer cell resistant to chemotherapy.
A second wave of EDV cells is then accepted by the cancer cell and releases chemotherapy drugs, killing the cancer cell.
"The beauty is that our EDVs operate like 'Trojan horses'. They arrive at the gates of the affected cells and are always allowed in," said MacDiarmid.
'Hottest areas'
"We are playing the rogue cells at their own game. They switch-on the gene to produce the protein to resist drugs, and we are switching-off the gene which, in turn, enables the drugs to enter."
RNA interference, or RNAi, is designed to silence genes responsible for producing disease-causing proteins and is one of the hottest areas of biotechnology research.
RNA was the basis of the 2006 Nobel Prize in medicine.
Dozens of biotechnology companies are looking for ways to manipulate RNA to block genes that produce disease-causing proteins involved in cancer, blindness or AIDS.