“The hand was going to be used in the commission of the offence,” said advocate Mluleki Chiti, representing two of five people accused of plotting to kill Mkhize.
Chiti, representing Themba Xaba and Sizwe Mkhize (no relation to Zweli), did not explain how the limb would be used in the murder.
It is however common knowledge that body parts are sometimes used as muti when people commit crime.
Chiti said the body part was found at Mkhize’s flat in Durban a day before he was arrested with Xaba, Jackson Chili, Mlungisi Xulu, and Sthembiso Mthembu as they were allegedly on their way to kill the premier.
Chiti said police took the hand, and that Mkhize was not arrested on that day because he explained to police it was going to be used by "certain people" plotting to kill the premier.
While the state alleges the five were involved, the accused claim other people hatched the plan.
They had so far however refused to divulge the names of these alleged plotters during their bail application, which was expected to be concluded next Tuesday.
Investigating officer Sbusiso Zungu said something was taken from Mkhize’s flat, but said it was not a human body part.
Chiti told the court his clients had told police about the people who were involved in the plot as far back as 2009.
Mkhize last month told the court he was a police spy, a claim dismissed by police, who said he was not on the register of informers.
The court on Friday heard it was unclear whether Sizwe Mkhize was investigated for allegedly trying to recruit soldiers from Burundi to destabilise the province.
"I am not sure whether there is any investigation with regards to that matter," Zungu said.
He was being questioned about the so-called "operation Coca Cola and Siyayinyomfa", which the state alleges Sizwe Mkhize established to destabilise KwaZulu-Natal by burning hospitals and schools.
The five face charges of possession of illegal firearms and ammunition and conspiracy to commit murder.