Dhlomo-Mkhize is filing for divorce allegedly citing her marriage was devoid of trust.
She is believed to be fed up with the marriage and wants nothing but a divorce.
This week she instructed her Johannesburg-based lawyers, Brian Kahn Inc Attorneys, to handle all divorce proceedings, including a settlement with regard to the maintenance of their two children and the issue of their house in Bryanston.
City Press was reliably told she wanted a peaceful out-of-court settlement.
The couple were married in a colourful wedding in 1992 in Durban. Their impending divorce is set to put to rest long standing rumours in high social circles that the two were experiencing problems in their marriage.
A family friend told City Press Dhlomo-Mkhize was not happy and had had enough after her husband allegedly "cheated" on her.
Dhlomo-Mkhize and her husband were rarely seen together in public during the last few years - fuelling speculation that all was not well in their marriage.
She was recently seen in Mauritius doing a photo-shoot for a local magazine with South African multi-millionaire Mark Shuttleworth.
Mkhize did not accompany her on the trip.
Mkhize was recently seen in Durban in the company of his brother Lindelani - an executive at Sony Music - and family friends during an annual gathering organised by Lindelani.
Dhlomo-Mkhize, for the first time, did not attend the event.
A close family friend said the couple's marriage has been unstable for some time and efforts by their elders to save the marriage were unsuccessful.
"Mkhize, though a wonderful dad to his children, has not been faithful to his wife and would at times come back home late after socialising with friends," the family friend told City Press.
This apparent neglect contributed to Dhlomo-Mkhize filing for divorce.
Another friend said Mkhize, although he had his faults, should not be the sacrificial lamb as "it took two people to build a marriage".
Asked about the divorce, Dhlomo-Mkhize confirmed, through a statement, that she and her husband had "irreconcilable differences and were ending their marriage amicably".
She said they would like their privacy respected and would grant no interviews.
Dhlomo-Mkhize said the matter was personal and she and her husband had no comment, except to say as marriage partners they were putting their two children first.
City Press has reliably learnt the couple has explained the situation to their children, who are said to be coping well with the impending divorce.
Dhlomo-Mkhize is credited for having turned True Love around. It is now the largest English glossy women's magazine in South Africa. Its readership has grown from just over 500 000 to 1.9 million in the past eight years.
Last year Dhlomo-Mkhize also signed a contract with LUX to appear in the brand's television commercials as the Face of LUX for Africa and the Indian Ocean Islands.
Her husband had a successful dentistry practice before venturing into business. He is now the health care division managing director of a black information technology firm.