The Cape Times reported that Daniel Sass, 52, died in the Tygerberg hospital on Tuesday morning of head, neck and spinal injuries.
A Golden Arrow bus veered off the Mew Way bridge after being stoned by protesters, and crashed into several shacks on Friday night.
The bus driver, Sandile Hoko, was killed and about 25 people were injured.
Sass's daughter Thembeka Lamont told the newspaper she was now an orphan.
"Who will look after us? All they have caused is pain, and not just for me, but for all who have been affected," she said.
"If people want houses, services or anything, why not go to the relevant authority offices and tell them their needs?"