Stem cells boost hopes of ending deafness

2012-09-13 10:30

Paris - Scientists working with deaf gerbils said on Wednesday they had found a way of coaxing early stem cells into specialised ear cells that helped the rodents hear sound once more.

The gerbils had been given a chemical to damage key nerve cells called spiral ganglion neurons (SGNs). These transmit to the brain the signals that are picked up by "hair" cells, which respond to noise.

In a study published in the journal Nature, a team led by Marcelo Rivolta at Britain's University of Sheffield said they had found a way to turn human embryonic stem cells into precursors of these vital ear cells to reverse the deafness.

Stem cells are infant cells that develop into the specialised tissues of the body.

They have sparked great excitement as they offer hopes of rebuilding organs damaged by disease or accident.


Stem cells taken from an early embryonic stage are the most prized in research because they have the greatest versatility, but the big challenge is ensuring that they differentiate into the right tissue.

Rivolta nurtured the stem cells in a serum bath to gain "otic pregenitor" cells before gently implanting them in the gerbils.

After 10 weeks, the animals had, on average, recovered 46% of their hearing loss, according to electrodes that measured their brains' response to sound.

Their average level of detection was around 50 decibels, which is equivalent to a conversation in quiet surroundings.

"The range of recovery went from modest to almost complete, which is remarkable considering the technical challenges involved in the procedure," the paper said.

Many obstacles remain before this laboratory trial can be used on humans, a process that is closely regulated for safety.

But the researchers said that, if these hurdles are overcome, stem cell therapy could one day offer hope for deaf people when used with a cochlear implant, a device that circumvents loss of hair cells.

  • jody.beggs - 2012-09-13 10:59

    If there was a god , we would not need science for miracles. Yay science.

      dmostert2 - 2012-09-13 16:26

      @Mememan (This is not a Xtian counter... I'm not one) You might want to add "for those that can afford them' before tooting science's horn like that. Science also created some good anti-retrovirals, but those aren't the ones your local clinic is distributing. So these breakthroughs, awesome as they are, are not always relevant to the poor. Which there are a lot of around these parts.

      dmostert2 - 2012-09-13 16:30

      @dilligaf Science might not discriminate, but economics does. So yay for those that can afford it.

      andrea.bower.121 - 2012-09-14 10:48

      We could say that it is due to God that we have science and that this is God's way(through science) of answering our prayers. Maybe God does want us to have some doubt, but at the same time wants us to have hope

      jody.beggs - 2012-09-17 10:05

      @andrea.bower.121 fail ... What happened to faith ? Nowhere in the buy bull does it say rely on man or material things , it says the opposite ! Why are you lying for Jesus ?

  • Tony Lapson - 2012-09-13 11:18


  • john.halfpenny.395 - 2012-09-13 15:45

    I hope those researchers are praying hard that their hard work will pay off in the end so that they can give the Glory to our Lord Jesus... LOL

      jody.beggs - 2012-09-17 10:06

      The is no god or jesus or we would not need science and medicine. Please stop lying...

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