Study groundbreaking

2019-01-16 06:02
Nthabiseng MokoenaPhoto: Supplied

Nthabiseng MokoenaPhoto: Supplied

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A bright researcher of the University of the Free State (UFS), Nthabiseng Mokoena, is one step closer to treating the HIV/AIDS pandemic.

South Africa has the biggest high-profile HIV epidemic in the world, with an estimated seven million people living with HIV in 2015.

In the same year, there were 380 000 new infections, while 180 000 South Africans reportedly died from AIDS-related illnesses.

Invasive fungal infection, common in certain groups of patients with immune deficits, is a serious driver of global morta­lity in the context of the global HIV pandemic.

“Despite a major scientific effort to find new cures and vaccines for HIV, hundreds of thousands of HIV-infected individuals continue to die yearly from secondary fungal infection.

“Intensive research needs to be done to help reduce the unacceptably high mortality rate due to the infection in South Africa,” said Mokoena.

She is a master’s student of Prof. Carlien Pohl-Albertyn, who is heading the Research Chair in Pathogenic Yeasts in the Department of Microbial, Biochemical and Food Biotechnology at the UFS.

Mokoena received her master’s degree at the December 2018 graduation cere­mony of the UFS.

Her thesis is titled: “Caenorhabditis elegans as a model for Candida albicans-Pseudomonas aeruginosaco-infection and infection induced prostaglandin production”.

Research chair in pathogenic yeasts

Earlier in 2018, the National Research Foundation approved the Research Chair in Pathogenic Yeasts.

One of the projects of the group of scientists in this chair includes a study of the interaction between the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa in different hosts, using a variety of infection models.

In her research, Mokoena studied the response of infectious pathogens such as yeasts and bacteria, using a nematode (little roundworm) as an infection model to mimic the host environment.

Nematodes have numerous traits similar to humans. It is thus a good alternative for humans as infection models, as it is unethical to use the latter.

Nematodes have a number of advantages, including its low cost and fast reproduction and growth.

Mokoena monitored the survival of the nematodes to see how infectious the pathogens are, especially in combination with each other.

Role of infection model for drug development

When these two pathogens were studied in a lab (in vitro), it was found that they can inhibit each other, but after studying them in the infection model (in vivo), Mokoena showed that these pathogens are more destructive together.

This finding has a huge impact for the pharmaceutical industry, as it can provide information on how drugs need to be designed to fight infectious diseases where multiple organisms cause co-infections.

Many pathogens are resistant to drugs. Through this model, drugs can be tested in a space similar to the human body. Seeing how pathogens react to drugs within a space similar to the human body, can contribute to drug development.

Not only are drugs developed more effectively through this model, it is also less expensive.

It is the first time that the combination of this yeast and this bacterium is being experimented on in this model.

Mokoena is currently working on an article based on her research about drug development in infection models, which will be published under the Research Chair in Pathogenic Yeasts.


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