Dressed in all-white, the singer dedicated the song to his wife Chrissy Teigen, whispering: "This is for Chrissy."
"We will never break/Built on a foundation/Strong enough to stay/We will never break/As the water rises/And the mountains shake/Our love will remain," the song says in part.
The emotional tribute comes just weeks after John and Chrissy announced that they lost their baby due to pregnancy complications.
"My heart, obviously all of our hearts, go out to you both in this very difficult time," Kelly Clarkson, who hosted the award show, said before introducing John.
Compiled by Nikita Coetzee