"I just want to make it clear to everybody there is no subject that's off-limits," Oprah says in the clip.
She asks Meghan: "Were you silent or were you silenced?" before adding: "Almost unsurvivable sounds like there was a breaking point."
Later in the clip, Prince Harry joins the interview, which sees him talk about Princess Diana. "My biggest concern was history repeating itself," he says.
Oprah concludes the clip with a phrase sure to rile up royal watchers: "You've said some pretty shocking things here..."
Oprah With Meghan and Harry: A CBS Primetime Special will air on Sunday, 7 March in the US.
SEE THE SNEAK PEEK HERE: