The pre-trial conference of Xolile Mngeni and Mziwamadoda Qwabe, accused of murdering honeymooner Anni Dewani, is expected to begin in the Western Cape High Court on Friday.
Mngeni and Qwabe face charges of kidnapping, robbery with aggravating circumstances, murder, and two counts relating to the illegal possession of a firearm and ammunition.
South Africa is trying to extradite Anni's husband, businessman Shrien Dewani, from the United Kingdom to stand trial for her murder.
An order for his extradition was signed by the UK secretary of state in September, but Britain's High Court temporarily halted the extradition on mental health grounds, saying it would be "unjust and oppressive".
He would be extradited to South Africa as soon as he was fit.
Dewani is being treated in a mental health hospital in his hometown of Bristol, western England.
Anni, 28, was shot dead in an apparent car hijacking while she and her husband were on honeymoon in Cape Town in November 2010.