Britain's royal officials announced Thursday that starting September, the royal will train for about five months as a helicopter pilot with East Anglian Air Ambulance. If successful, he will join the charity group, based in Cambridge, next spring.
Kensington Palace said Thursday the stint will be William's main job, though he will also continue to take on royal duties and engagements both in Britain and overseas.
The royal's duties will include flying both day and night shifts, and working with medics to respond to emergencies ranging from road accidents to heart attacks.
"The pilot is part of the team and he will be looking after patients with conditions that would be horrifying for many, and some pilots may not like that very much," said Alastair Wilson, the charity's medical director. "Compared to his role as a search-and-rescue pilot, he may be dealing with more injury patients than he is used to, but I'm sure he will adapt very well to that."
The job will build on William's experience as a Royal Air Force search-and-rescue pilot, a position he qualified for in 2012 after serving other military duties.
He left that job last September, shortly after his and his wife Kate's first son, Prince George, was born.
William will be paid a salary for the new job, which he will donate in full to charity, officials said.