Equity markets were mixed Tuesday as investors took a breather after the previous day's rally, with the mood dampened by news that a vaccine trial had been halted after a volunteer fell ill.
While Wall Street provided a strong lead thanks to a surge in tech stocks, regional traders struggled to take up the baton with sentiment continuing to be kept in check by spiking virus infections and the reimposition of some lockdowns around the world.
There was little movement after remarks by a top Democrat who said the House should not expect any action on a new stimulus this week, making a rescue deal even more unlikely before the November 3 election.
Republicans for their part have rejected the $1.8 trillion offer put forward by the White House last week.
Still, there is a broad expectation that a bill will eventually be passed - and with Joe Biden well ahead in polls and Democrats possibly taking both arms of Congress, talk is of a bigger package.
Analysts said the prospect of a big cash injection into the struggling economy was trumping worries about a possibly less-pro-business Biden, whose huge poll leads are also easing worries about a drawn-out result.
"For now it seems the reduced uncertainty over the election and the promise of large-scale fiscal stimulus is evidently overriding concerns about higher corporate taxes and more regulation," said National Australia Bank's Ray Attrill.
"'We can worry about that later, if ever' seems to be the current investor market mindset."
But for now, worries about the development of a vaccine are playing on investors' minds after Johnson & Johnson said it had temporarily halted its trial after a participant fell sick.
The firm said serious adverse events were "an expected part of any clinical study, especially large studies", adding company guidelines allowed officials to pause a study to determine if the problem was related to the drug in question and whether to resume trials.
The news dealt a blow to hopes for an effective treatment for the disease, which as killed more than a million people, infected tens of millions and plunged the global economy into recession.
Tokyo, Sydney, Mumbai, Singapore, Jakarta and Wellington rose, but Seoul, Taipei and Manila dipped. Hong Kong was closed because of a typhoon in the city.
Shanghai was flat but pared earlier losses after data showed Chinese imports had smashed forecasts last month, a further indication the world's top economy was getting back on track.
While the news was welcome, Chinese customs spokesman Li Kuiwen warned the spread of Covid-19 and the ensuing economic carnage made the global landscape "increasingly grim and complicated".
London opened flat as officials revealed Britain's unemployment rate had jumped to 4.5% in June-August from 4.1% in May-July.
Paris and Frankfurt fell.