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28 Sep 2007

Androcur side effects
Hi I am about to take androcur for the 3rd month. I have noticed my breasts are tender nearly all the time and fuller, as I have tiny breasts its easily noticeable. I am also very tired most of the time. I've also lost weight tho am not eating less.

I want to know if these effects are normal?

Also I want to know if I will have to take Androcur for life if I want to control my hirsutism. When I want to have more kids, i'll stop and then continue after I give birth? I'm 33 and have one child.

If I stop taking it, will I be very hairy again? I can't bear the thought of taking a medication for life.

I'm on diane 35 too. The indications are acne and hirsutism.
Answer 7,119 views
Expert
Pharmacist
pharmacist

01 Jan 0001

Your cotor will be the only one making the call for how long you''l have totake your meds.

Androcur side effects are listed as:

SIDE EFFECTS AND SPECIAL PRECAUTIONS
Administration of high doses of cyproterone acetate during the hormone-sensitive differentiation phase of the genital organs (starting roughly on day 45 of gravidity) could cause feminisation effects in male foetuses. Observation of male newborn children who had been exposed in the uterus to cyproterone acetate revealed no indications of feminisation. However, pregnancy is a contra-indication for the use of Androcur. Women of child-bearing age should only be treated if reliable contraceptive measures are taken at the same time.
Recognised first-line tests of genotoxicity gave negative results when conducted with cyproterone acetate. However, there is some evidence of genotoxicity as further tests showed that cyproterone acetate was capable of producing adducts with DNA (and an increase in DNA repair activity) in liver cells from rats and monkeys and also in freshly isolated human hepatocytes. This DNA adduct formation occurred at exposures that might be expected to occur in the recommended dose regimens for cyproterone acetate. One in vivo consequence of cyproterone acetate treatment was the increased incidence of focal, possibly pre-neoplastic, liver lesions in which cellular enzymes were altered in female rats.
The clinical relevance of these findings and how these findings relate to the risk of developing benign and malignant liver tumours in humans is presently unknown. Clinical experience to date would not support an increased incidence of hepatic tumours in man. Nor did investigations into the tumorigenicity of cyproterone acetate in rodents reveal any indication of a specific tumorigenic potential. However, it must be borne in mind that sexual steroids can promote the growth of certain hormone-dependent tissues and tumours.
In rare cases benign, and in even rarer cases malignant, liver tumours leading in isolated cases to life-threatening intraabdominal haemorrhage have been observed after the use of sex steroids to which the substance contained in Androcur 10 mg also belongs. If severe upper abdominal complaints, liver enlargement or signs of intraabdominal haemorrhage occur, a liver tumour should be included in the differential-diagnostic considerations.
Changes in body-weight and libido, a feeling of tension in the breasts, tiredness, diminished vitality, inner restlessness and depressive moods may occur.
Attention is drawn to the special notes on side effects, reasons for immediate discontinuation of treatment as well as all relevant data contained in the package insert of the combination oral contraceptive preparation.
Disturbances of liver function, acute and fulminant hepatitis have been reported with high-dose Androcur treatment. During treatment, liver function should be checked regularly.
In diabetics, carbohydrate metabolism should also be monitored particularly carefully.
Before the start of therapy, a thorough general medical and gynaecological examination (including the breasts and a cytological smear of the cervix) should be carried out. Pregnancy must be excluded in women of child-bearing age.
Ovulation is inhibited under the combined cyclical treatment, so that a state of infertility exists. This is essential because if Androcur were taken during pregnancy, the properties of the preparation could lead to signs of feminisation in male neonates.
A high-dosed treatment may reduce the function of the adrenal cortex, particularly the adrenocortical response to stress.
If, during the combined cyclical treatment, slight "unscheduled" bleeding occurs, tablet-taking should not be interrupted. However, if the bleeding is heavy, the patient should consult her doctor.
It should be pointed out to patients whose occupation demands great concentration (eg road users and machine operators) that Androcur can lead to tiredness and diminished vitality and can impair the ability to concentrate.
Androcur 10 mg should not be given before the conclusion of puberty since an unfavourable influence on the longitudinal growth and the still unstabilised axes of endocrine function cannot be ruled out.
Androcur should be used with caution in cardiovascular disease, ischemic heart disease, cerebrovascular disease and hypertension.
Haemoglobin and red cell counts may decrease on therapy with Androcur.
The information provided does not constitute a diagnosis of your condition. You should consult a medical practitioner or other appropriate health care professional for a physical examination, diagnosis and formal advice. Health24 and the expert accept no responsibility or liability for any damage or personal harm you may suffer resulting from making use of this content.
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