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29 Jun 2011

Cyclizine in pregnancy?
According to the Daily Drug Use, Vomifene (Buclizine) is Risk Factor C (not proven safe in pregnancy) while Valoid (Cyclizine) is a Risk Factor B? What to do, since we''ve always been taught the contrary!
Answer 1,036 views
Expert
Pharmacist
pharmacist

01 Jan 0001

Hi

Many a pharmacist have noted this!

According to Schaefer et al. (2007), no increased risks of congenital abnormalities, above the background rate for the population, have been reported when cyclizine have been used in therapeutic doses.

Cyclizine has been assigned to pregnancy category B by the FDA. Although cyclizine has been shown to be teratogenic in animals, a study of cyclizine use in the first trimester of human pregnancy found no increase in the rate of malformations. Cyclizine is only recommended for use during pregnancy when benefit outweighs risk.

Buclizine has indeed been assigned to pregnancy category C by the FDA.

The fact Buclizine is commonly prerscribed in SA possibly indicates that it is a low risk drug.


1. Schaefer, C., Peters, P. and Miller, R.K. (Eds.) (2007) Drugs during pregnancy and lactation: treatment options and risk assessment. 2nd edn. Oxford: Academic Press.
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