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Question

13 Jan 2003

The XXX Syndrome
Have you got any information regarding the XXX Syndrome?
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Expert
CyberDoc
CyberDoc

01 Jan 0001

Reshma, it's a sex chromosome abnormality in which there are three X chromosomes, resulting in a phenotypic female.

About 1/1000 apparently normal females have 47,XXX. Other physical abnormalities are rare. Sterility and menstrual irregularity sometimes occur. Mildly impaired intellect with IQ scores averaging just below 90 and associated school problems occur when compared with siblings. Advanced maternal age increases risk, and the extra X chromosome is usually maternally derived.
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