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11 Dec 2005

Prozac tolerance
I have been on antidepressants for 14 yrs. Apart from a few variations, mostly on Prozac - for the past four years on Lillyfluoxitine. Many of the old symptoms are re-occuring and I am left wondering if my Prozac needs Prozac? I've asked to go on to "natural" alternatives, but have been told it's unwise after such a long spell.
Any suggestion?
Answer 451 views

01 Jan 0001

Firstly, there ARE NO "natural" alternatives. The only "natural" remedy which has received some testing, with SOME evidence of benefits in mild depression, is St John's Wort, and that evidence is still equivocal, and ONLY applies to mild not significant depression --- and when it works, it does so apparently from the same chemical effects as Prozac, so if Prozac isnt working for you, the Wort surely wont.
There is no evidence of anyone developing "tolerance" to prozac / Fluoxetine, or to any other antidepressant. But it is conceivable that the chemical nature of a depression might alter to some extent. and become more sensitive to a different medication. What you need is to see again your psychiatrist ( or maybe seek a second opinion ) for a re-assessment of the currrent situation, and a consideration of alternative antidepressants. Fortunately there are several others which, like Prozac, have equivalent and cheaper generic versions available.
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