Surgery cuts genetic breast cancer risk

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Women whose genes put them at a high risk of contracting breast cancer can dramatically reduce the danger by having a double mastectomy - but not eliminate it altogether, experts say.

The issue has been thrown into the spotlight with Hollywood star Angelina Jolie's announcement that she had her breasts surgically removed after tests revealed she carried a genetic mutation that can lead to cancer.

Rocker Ozzy Osbourne's wife, Sharon, did the same last year.

About 0.2% of women carry a harmful mutation in the BRCA1 or BRCA2 gene that boosts their lifetime risk of contracting breast cancer to as much as 80% compared to about 10 percent for women without the gene.

"This is what many people would consider a sky-high risk," epidemiology professor Per Hall of Sweden's Karolinska Institutet told AFP. "For the few women who are carriers (of the mutation) this is definitely a good option," he said of surgery.

Mastectomy reduces a mutation-carrier's risk

Having a double mastectomy reduces a mutation-carrier's risk by about 90% to a level lower than that of women who don't carry the genetic flaw.

But it but can never eliminate the danger entirely.

"Even the most skilled surgeon will leave some tiny part of breast tissue behind," said Hall.

An estimated 458 000 women died of breast cancer - the most common cancer type among women - in 2008, according to the World Health Organisation (WHO).

Survival rates vary greatly, from 80% in the developed world to under 40% in poor countries that have fewer early-detection programmes.

The cost of genetic screening can be prohibitive - ranging from several hundred to several thousand dollars, says the US-based National Cancer Institute.

On its website, the WHO says early detection remains the "cornerstone" of its cancer strategy as preemptively screening asymptomatic people was a "far more complex undertaking".

DNA, the blueprint for life, comprises four basic chemicals called A (adenine), C (cytosine), T (thymine) and G (guanine) strung together in different combinations along a double helix.

Problems in gene function

Sometimes a "spelling mistake" in the A, C, T, G combinations can cause problems in gene function.

But carrying a mutation does not necessarily mean a person will develop cancer - factors like lifestyle also play a role.

A study in 2005 concluded that a fifth of breast cancer deaths worldwide could be attributed to alcohol use, excessive weight and physical inactivity.

Delayed pregnancy and not breastfeeding are factors considered to increase one's chances of contracting breast cancer.

Age is a major factor - most breast and ovarian cancers occur in women over 50, though women with the BRCA mutations often get ill at an earlier age.

Mutations in the BRCA (BReast CAncer susceptibility) genes, which normally act as tumour suppressors, also increase ovarian cancer risk.

Clinical geneticist Clare Turnbull at the Royal Marsden Hospital in London said women who carry the mutation are generally offered intensive MRI and mammogram screening so any cancer can be caught and treated early.

"That is one option, and for many women particularly young women, that's the option they choose," she told AFP.

Reducing cancer risk

"Other women feel that they would like to take a more interventional approach and try and reduce the likelihood of them getting cancer in the first place", such as a double mastectomy.

"It is not uncommon."

The London-based Breast Cancer Campaign said Jolie's openness would help raise crucial awareness of genetic breast cancer risk.

"Deciding whether to have preventative surgery is a heart rending decision for women like Angelina but we know it's a vital way of saving lives," the campaign's chief executive Delyth Morgan said.

"This is a stark reminder of how much more research we need to do to give women more knowledge, choice and life-saving options to reduce their risk."

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