In-vitro fertilisation increases tumour risk

Women who were given hormone treatment for in-vitro fertilisation (IVF) ran twice the risk of ovarian malignancies compared with counterparts who did not undergo IVF, a study said.

Doctors in the Netherlands compared the long-term health of more than 19,000 women who had received at least one IVF ovarian stimulation treatment with just over 6,000 similarly infertile counterparts who had not been treated for IVF.

Of the 25,000 women they studied, 77 developed ovarian malignancies in the ensuing 15 years, a risk that in absolute terms was very low.

But in relative terms, the numbers were much higher in the IVF group, which had 61 out of the 77 cases compared to 16 in the non-IVF group.

Two-fold increase

Thirty of the 61 were cases of invasive ovarian cancer, which usually requires extensive surgery and chemotherapy and has a low survival rate.

The other 31 cases were borderline ovarian tumours, which have low malignancy potential and are rarely fatal but require major surgery.

After taking into account the age and how many children if any the women had had, as well as other factors that could skew the results, the researchers found a two-fold increase in the risk of ovarian malignancies in the IVF group.

But the risk did not increase with more IVF cycles, a surprise finding that will be probed further.

The study, appearing in the European journal Human Reproduction, is based on data from national health registries and women diagnosed with sub fertility problems at the Netherlands' 12 IVF clinics between 1980 and 1995.

(Sapa, October 2011) 

Read more:

IVF

Ovarian cancer

We live in a world where facts and fiction get blurred
In times of uncertainty you need journalism you can trust. For only R75 per month, you have access to a world of in-depth analyses, investigative journalism, top opinions and a range of features. Journalism strengthens democracy. Invest in the future today.
Subscribe to News24
Voting Booth
Have you entered our Health of the Nation survey?
Please select an option Oops! Something went wrong, please try again later.
Results
Yes
29% - 9753 votes
No
71% - 24014 votes
Vote