Metformin doesn't help obese teens with type 1 diabetes


Metformin is the standby drug for millions of people with type 2 diabetes, but a new study finds that adding it to insulin therapy won't boost blood sugar control for overweight teens with type 1 diabetes.

Obesity and puberty

In type 1 diabetes, which comprises about 5 percent of diabetes cases, the body is unable to produce the insulin it needs. So, supplemental insulin is a must for people with the disease.

The new study was led by Kellee Miller of the Jaeb Centre for Health Research in Tampa, Florida. As her team explained, young people with type 1 diabetes are at even higher metabolic risk if they become overweight or obese, especially in adolescence.

That's because both obesity and puberty may cause the patient to require higher levels of supplemental insulin, complicating blood sugar control, the researchers said.

Read: Metformin causes modest weight loss 

Metformin – a pill taken to help lower blood sugar – is widely used to treat type 2 diabetes. However, prior studies of how it might affect blood sugar control in teens with type 1 diabetes have been inconclusive, Miller's team noted.

The new study involved 140 overweight and obese patients ages 12 to 19 with type 1 diabetes. Each was randomly assigned to take either metformin or a placebo, along with their insulin, for six months.

The result: Patients taking metformin showed no improvement in blood sugar (glycaemic) control over those taking the placebo. A small beneficial effect from the metformin was seen early on in the study, but it disappeared as the weeks went on.

Some benefits

Furthermore, patients who took metformin had more gastrointestinal side effects than those who didn't take the drug, Miller's team said.

"These results do not support prescribing metformin to adolescents to improve glycaemic control," the researchers wrote in the 1 December issue of the Journal of the American Medical Association.

Read: Diabetes drug may reduce dementia 

One expert in diabetes care said there could still be a role for metformin for these patients, however.

Dr Spyros Mezitis is an endocrinologist at Lenox Hill Hospital in New York City. He pointed out that the addition of metformin did seem to offer patients some benefits.

"Metformin did decrease the amount of insulin used and was associated with weight loss," Mezitis said, although it "did not reduce blood pressure or cholesterol profiles".

Metformin is also known to cut glucose production by the liver, curb harmful insulin resistance and reduce appetite, he added.

"I think more randomized trials are needed before practicing physicians change their practice of using metformin in adolescent overweight type 1 diabetic patients," Mezitis concluded.

Read more: 

Managing Type 1 diabetes can stress teens  

Dealing with childhood diabetes  

Diabetic kids in the classroom 

We live in a world where facts and fiction get blurred
In times of uncertainty you need journalism you can trust. For 14 free days, you can have access to a world of in-depth analyses, investigative journalism, top opinions and a range of features. Journalism strengthens democracy. Invest in the future today. Thereafter you will be billed R75 per month. You can cancel anytime and if you cancel within 14 days you won't be billed. 
Subscribe to News24
Voting Booth
Zama zama crackdown: What are your thoughts on West Village residents taking the law into their own hands?
Please select an option Oops! Something went wrong, please try again later.
Authorities should bring in the army already
20% - 83 votes
Illegal miners can't be scapegoated for all crime
7% - 30 votes
What else did we expect without no proper policing
66% - 270 votes
Vigilante groups are also part of the problem
6% - 25 votes
Rand - Dollar
Rand - Pound
Rand - Euro
Rand - Aus dollar
Rand - Yen
Brent Crude
Top 40
All Share
Resource 10
Industrial 25
Financial 15
All JSE data delayed by at least 15 minutes Iress logo
Editorial feedback and complaints

Contact the public editor with feedback for our journalists, complaints, queries or suggestions about articles on News24.