Helpful bacteria may help detect liver cancers


In research with mice, scientists report that they've used a potentially beneficial strain of E. coli bacteria to help detect cancer in the liver that has spread from other locations.

Many cancers spread to the liver

Many types of cancer – including colon and pancreatic – tend to spread to the liver. The earlier these tumours in the liver are detected, the better the chances of successful treatment, said the researchers, from the Massachusetts Institute of Technology and the University of California, San Diego.

The researchers used a strain of E. coli that normally inhabits the liver. It is not an illness-causing strain of E. coli. Instead, this strain is considered a helpful germ, similar to probiotic bacteria found in yogurt. The researchers reprogrammed the E. coli bacteria to produce a luminescent signal that can be detected with a simple urine test.

Read: Treating liver disease

The bacteria was given by mouth to mice with colon cancer that had spread to the liver. The bacteria "colonized" nearly 90 percent of the colon cancer tumours in the livers of the mice, the researchers reported.

None of the mice suffered any harmful side effects, according to the study. However, results from animal studies frequently don't produce similar results in humans.

Difficult to detect

The findings were published in the journal Science Translational Medicine.

The liver is hard to image with conventional imaging techniques such as CT or MRI, making it difficult to detect tumours that have spread to the organ, the researchers noted.

Using the E. coli test, the researchers said they were able to detect tumours not spotted by existing imaging methods.

Read: Preventing liver disease

The new technique could be most useful for monitoring patients after they have had a colon tumour removed. That's when they're at high risk for cancer recurrence in the liver, according to study author Sangeeta Bhatia, a professor of health sciences and electrical engineering and computer science at MIT in Cambridge, Massachusetts.

The researchers said they're also investigating whether they can use these helpful bacteria to treat cancers.

Read More:

Liver cancer (primary)

New test may help diagnose liver problem in kids

Olive oil protects liver

Image: Escherichia coli culture on Agar plates from Shutterstock

We live in a world where facts and fiction get blurred
In times of uncertainty you need journalism you can trust. For 14 free days, you can have access to a world of in-depth analyses, investigative journalism, top opinions and a range of features. Journalism strengthens democracy. Invest in the future today. Thereafter you will be billed R75 per month. You can cancel anytime and if you cancel within 14 days you won't be billed. 
Subscribe to News24
Voting Booth
Zama zama crackdown: What are your thoughts on West Village residents taking the law into their own hands?
Please select an option Oops! Something went wrong, please try again later.
Authorities should bring in the army already
8% - 412 votes
Illegal miners can't be scapegoated for all crime
58% - 2962 votes
What else did we expect without no proper policing
31% - 1555 votes
Vigilante groups are also part of the problem
3% - 146 votes
Rand - Dollar
Rand - Pound
Rand - Euro
Rand - Aus dollar
Rand - Yen
Brent Crude
Top 40
All Share
Resource 10
Industrial 25
Financial 15
All JSE data delayed by at least 15 minutes Iress logo
Editorial feedback and complaints

Contact the public editor with feedback for our journalists, complaints, queries or suggestions about articles on News24.