Dogs help in fight against bone cancer


Man's best friend will be part of an effort to find better treatments for a type of bone cancer in children and young adults, researchers report.

Dogs who are suffering from osteosarcoma will be treated with drugs that are already approved by the US Food and Drug Administration for other uses, to see how well these medications battle the bone cancer, said Dr Joy Fulbright, a paediatric oncologist with Children's Mercy Hospital in Kansas City, Missouri.

"This is one of the cancers that is the same type of cancer in both dogs and humans, and dogs tend to be able to process drugs similarly to how humans do," Fulbright said. "Ideally, we'd like to find an agent that's not as toxic as the chemotherapy we currently use."

Read: Bone drug may prevent breast cancer  

Doctors are hoping that they'll find drugs that are effective against osteosarcoma in both dogs and humans. And, because these medications are already FDA-approved, they should be able to put them to use very quickly.

"It usually takes up to 15 years to get a drug from bench side to patient," Fulbright said. "We're hoping to decrease that time if we can find a drug that's already FDA-approved."

New treatments a challenge

Finding new treatments for osteosarcoma has been a challenge because it's an uncommon cancer in humans. Only about 800 people are diagnosed with the disease each year, about 400 of those are in children and teens, according to the American Cancer Society.

The five-year survival rates for people diagnosed with osteosarcoma before it has spread can be as high as 80 percent. If the cancer has spread, five-year survival rates drop to between 15% and 40%, according to the cancer society.

"We haven't improved the survival rate in the last 20 years," Fulbright said.

However, osteosarcoma is far more common in dogs than it is in people. About 10 000 cases are diagnosed each year, according to the study authors.

Currently, the researchers are pre-testing drugs in the laboratory using osteosarcoma cells taken from both humans and canines.

Dogs with bone cancer

The most promising drug candidates from this phase will then be tested in dogs that have been diagnosed with bone cancer, to see which work best with the least side effects. Vets at the Colorado State University College of Veterinary Medicine will identify canine candidates for the study and treat them with the drugs selected by researchers. No dogs will be given cancer for this study; the dogs must have naturally occurring osteosarcoma.

After identifying drugs that work for dogs, doctors hope to move on to human trials using the same medications.

Read: New hope for deadly bone cancer

Canines are commonly used in medical research, said Nicole Duffee, director of education and scientific affairs for the American Association for Laboratory Animal Science.

Their use in this study makes sense because osteosarcoma "is a naturally occurring condition in dogs, especially in large dogs," Duffee said.

Duffee noted that while the study is focused on a human treatment for osteosarcoma, it could also lead to improved bone cancer treatments for dogs.

The study is being funded with a $500 000 grant from the Midwest Cancer Alliance.

Read more:

Dogs helping in cancer fight
Dogs sniff out ovarian cancer
New cancer treatment for dogs

We live in a world where facts and fiction get blurred
In times of uncertainty you need journalism you can trust. For 14 free days, you can have access to a world of in-depth analyses, investigative journalism, top opinions and a range of features. Journalism strengthens democracy. Invest in the future today. Thereafter you will be billed R75 per month. You can cancel anytime and if you cancel within 14 days you won't be billed. 
Subscribe to News24
Voting Booth
The ANC's leadership race is heating up. Who do you think will be elected party president at Nasrec in December?
Please select an option Oops! Something went wrong, please try again later.
Nkosazana Dlamini-Zuma has got it in the bag
7% - 749 votes
I foresee a second term for Cyril Ramaphosa
83% - 8728 votes
Don’t discount a Zweli Mkhize win
10% - 1039 votes
Rand - Dollar
Rand - Pound
Rand - Euro
Rand - Aus dollar
Rand - Yen
Brent Crude
Top 40
All Share
Resource 10
Industrial 25
Financial 15
All JSE data delayed by at least 15 minutes Iress logo
Editorial feedback and complaints

Contact the public editor with feedback for our journalists, complaints, queries or suggestions about articles on News24.