Mutation helps ovarian survival

accreditation

A genetic mutation appears to help survival rates in women who suffer from a common type of ovarian cancer, a new study released found.

The research appearing in the January edition of the Journal of the American Medical Association (JAMA) showed the mutations were found in 6% to 15% of women with epithelial ovarian cancer (EOC).

Kelly Bolton of the National Cancer Institute, in Bethesda, Maryland and colleagues found that five-year overall survival was 36% for non-carriers of the gene mutations.

That compared to a 44% survival rate for mutations in the BRCA1 gene, and 52% in the BRCA2 gene, the research showed.

"BRCA1 carriers had a more favourable survival than non-carriers, which improved slightly after additional adjustment for stage, grade, histology, and age at diagnosis. BRCA2 carriers had a greater survival advantage compared with non-carriers, particularly after adjusting for other prognostic factors," the study found.

The study carried out a pooled analysis of 26 observational studies on ovarian cancer survival rates.

"Our study results have potentially important implications for the clinical management of patients with EOC. Most immediately, our findings can be used by health care professionals for patient counselling regarding expected survival," the authors said.

(Sapa, January 2012)

Read more:

Ovarian cancer- from natural standards

We live in a world where facts and fiction get blurred
In times of uncertainty you need journalism you can trust. For 14 free days, you can have access to a world of in-depth analyses, investigative journalism, top opinions and a range of features. Journalism strengthens democracy. Invest in the future today. Thereafter you will be billed R75 per month. You can cancel anytime and if you cancel within 14 days you won't be billed. 
Subscribe to News24
Voting Booth
The ANC's leadership race is heating up. Who do you think will be elected party president at Nasrec in December?
Please select an option Oops! Something went wrong, please try again later.
Results
Nkosazana Dlamini-Zuma has got it in the bag
7% - 529 votes
I foresee a second term for Cyril Ramaphosa
83% - 6487 votes
Don’t discount a Zweli Mkhize win
11% - 836 votes
Vote
Rand - Dollar
17.74
+0.5%
Rand - Pound
20.22
-0.1%
Rand - Euro
17.50
+0.2%
Rand - Aus dollar
11.59
+0.3%
Rand - Yen
0.12
+0.6%
Gold
1,705.34
+0.3%
Silver
20.93
+1.1%
Palladium
2,286.00
+2.8%
Platinum
914.39
+1.1%
Brent Crude
88.86
+4.2%
Top 40
58,778
+1.6%
All Share
65,157
+1.5%
Resource 10
63,237
+2.6%
Industrial 25
78,334
+1.0%
Financial 15
13,979
+1.2%
All JSE data delayed by at least 15 minutes Iress logo
Editorial feedback and complaints

Contact the public editor with feedback for our journalists, complaints, queries or suggestions about articles on News24.

LEARN MORE