Gene mutation doubles brain tissue loss

accreditation
iStock

People who carry a certain genetic mutation associated with Alzheimer's disease have double the rate of debilitating brain-tissue loss, a new study finds.

People with this mutation, known as the TREM2 gene variant, may also develop the disease three years earlier than expected, the researchers said.

"Our lab studies the rate of brain-tissue loss in elderly people, trying to discover factors that protect you as you age. We have never seen such a dramatic effect as with this genetic variant," study lead author Paul Thompson, a professor of neurology at the University of Southern California, said in a news release.

Wildfire of tissue loss

"If you carry this genetic mutation, we've found that there is this wildfire of tissue loss in the brain," he said.

In the study, the researchers mapped the effects of the gene mutation on the living brain using MRI scans. "This is the first study to use brain scans to show what this gene variant does, and it's very surprising," Thompson said.

The two-year study, published in The New England Journal of Medicine, showed that people with the TREM2 gene variant associated with Alzheimer's lose their brain tissue much more quickly.

The research involved nearly 500 adults from North America, averaging 76 years of age. One hundred had Alzheimer's disease, 221 had some impairment in memory or thinking, and 157 were healthy.

People with the gene mutation lost 1.4% to 3.3% more of their brain tissue than those who did not carry the mutation. This more extensive brain loss, which took place primarily in areas of the brain responsible for memory, also proceeded twice as quickly in those with the mutation.

Silent time bomb

"This gene speeds up brain loss at a terrific pace," Thompson said. "Carriers of this genetic mutation, who comprise about 1% of the population, lose about 3% of their brain tissue per year. This is a silent time bomb in 1% of the world."

Although healthy people usually lose less than 1% of their brain tissue per year, this loss is offset by the creation of new normal tissue from mental stimulation. For those with Alzheimer's, however, symptoms typically appear once about 10% of their brain tissue has been destroyed.

Thompson's team said the findings might have real importance in speeding research into effective Alzheimer's treatments because if studies targeted people who carry this mutation, answers to vital questions might become apparent more quickly.

"Enrolling those people who carry the mutation in clinical trials for Alzheimer's treatments could help us reach quicker and more meaningful results," Thompson said.

More information

The US National Institute on Ageing provides more information on Alzheimer's disease.

We live in a world where facts and fiction get blurred
In times of uncertainty you need journalism you can trust. For 14 free days, you can have access to a world of in-depth analyses, investigative journalism, top opinions and a range of features. Journalism strengthens democracy. Invest in the future today. Thereafter you will be billed R75 per month. You can cancel anytime and if you cancel within 14 days you won't be billed. 
Subscribe to News24
Voting Booth
Zama zama crackdown: What are your thoughts on West Village residents taking the law into their own hands?
Please select an option Oops! Something went wrong, please try again later.
Results
Authorities should bring in the army already
10% - 1546 votes
Illegal miners can't be scapegoated for all crime
54% - 8546 votes
What else did we expect without no proper policing
33% - 5228 votes
Vigilante groups are also part of the problem
3% - 501 votes
Vote
Rand - Dollar
16.17
+0.5%
Rand - Pound
19.63
+0.2%
Rand - Euro
16.59
+0.2%
Rand - Aus dollar
11.52
+0.2%
Rand - Yen
0.12
+0.2%
Gold
1,802.29
0.0%
Silver
20.82
0.0%
Palladium
2,227.50
0.0%
Platinum
966.00
0.0%
Brent Crude
98.15
-1.5%
Top 40
63,996
-1.0%
All Share
70,731
-0.8%
Resource 10
64,048
-2.8%
Industrial 25
86,577
-0.6%
Financial 15
16,059
+0.6%
All JSE data delayed by at least 15 minutes Iress logo
Editorial feedback and complaints

Contact the public editor with feedback for our journalists, complaints, queries or suggestions about articles on News24.

LEARN MORE