# What the latest Covid-19 stats can tell us - and what they can’t

• It used to be straightforward to decide when South Africa was in a Covid-19 wave. Everyone used the ministerial advisory committee’s formula. This year, things are a bit more complicated. Some researchers argue this method is no longer all that useful.
• If we use the MAC formula, the fifth wave started on May 7. But since this no longer translates into curfews, lockdowns or liquor bans, some researchers believe a new benchmark may be necessary.
• For everyday people, Covid-19 still holds some risk since new research shows even mild infection can cause brain damage or result in long Covid.

If we go by the sheer number of new, laboratory-confirmed SARS-CoV-2 infections, and use the formula the ministerial advisory committee (MAC) used in previous surges to calculate if a new Covid-19 wave had started, South Africa moved into a fifth Covid wave on May 7.

But not all scientists agree that we’re in a fifth wave per se - or that it matters that much.

The MAC formula says when the seven-day moving average of new cases exceeds 30% of the peak of the previous wave, we’re in a new wave.

The seven-day moving average is when you add up the seven past days of new cases, divide them by seven (so you get the average number of cases) and repeat that calculation for each new day so you can plot all the seven-day averages on a graph.

Because there would be a new seven-day average for each day, it’s called a “moving” average.

The reason why scientists use “moving” averages, is because these knock out big peaks and valleys (days with unusually high or low numbers) that could skew the bigger picture.

So a seven-day moving average gives them the chance to look at averages over a period of time and get a more representative view of what is happening.

The data journalism organisation, Media Hack, has calculated that the peak of South Africa’s previous (fourth) wave was on December 17 with 20 791 new infections.

Thirty percent of that is 6 237 infections. South Africa therefore tipped over that edge on Sunday, May 7, when the seven-day moving average was 6 282 infections, which signalled the start of a new wave.

But, Media Hack reports, on a provincial level, only the Northern Cape and Western Cape had seven-day moving averages by May 15.

Although the Free State (May 13), Gauteng (May 11) and KwaZulu-Natal (May 6) had reached this mark in May, their seven-day averages dropped below 30% again by May 15.

Limpopo, Mpumalanga and Northwest have not yet entered their fifth waves.

#### What is driving the current surge?

The Omicron variant, which drove South Africa’s fourth wave, is also driving the country’s current surge in infections, but the present uptick is fuelled by different forms of Omicron than in the fourth wave.

During our fourth wave a form of Omicron known as BA.1, was the main form of the virus circulating in the country. A new form of Omicron, BA.2, then took over and caused a temporary rise in infections when schools opened.

But in mid-January, yet another subvariant, BA.4, was detected in Limpopo, and at the end of February, another, BA.5, in KwaZulu-Natal. BA.4 and BA.5 have since been picked up in all provinces, and in April more than half of the SARS-CoV-2 test result samples that scientists analysed in South Africa, came out as BA.4 and BA.5.

Meanwhile there is “tentative promising news” with the BA.4 / BA.5-drivensurge flattening out and showing signs of slowing down, researcher Ridhwaan Suliman,reports, with the average proportion of Covid tests coming out positive now standing at a “steady 24%”.

#### The numbers say we’re in a fifth wave, but are we?

The question now, National Institute of Communicable Diseases (NICD) scientists say, is: Are the formulas we used to calculate if previous waves had started still relevant and can we trust the results?

The short answer on both accounts, according to the head of the NICD’s division of public health surveillance and response, Michelle Groome is: Probably not.

First of all, testing patterns have changed, which makes it hard to reliably compare the current testing data to the testing numbers of previous waves.

The NICD’s weekly testing reports show that fewer people are going for tests compared to previous waves. "People that have been vaccinated and/or had Covid-19 no longer seem to be going for Covid testing when they get sick. So overall, testing rates are low," says Groome.

Rapid antigen tests, as opposed to PCR tests only, are also now used more widely in South Africa. Because rapid test results don’t need to be analysed in a laboratory, as in the case with PCR tests, health workers who conduct the tests often fail to report the results to the National Health Laboratory Service, which keeps a record of test results.

So a smaller proportion of the actual test results are reported with the current surge than in previous waves, when PCR tests were mostly the only available test.

According to the epidemiologist Salim Abdool Karim, fewer people are choosing to test for Covid since they may not realise they’re ill. He explains: “The vast majority of infections in South Africa are either asymptomatic or mildly symptomatic”.

With no new variant (each previous wave was driven by a new variant) and because cases during the country’s interwave period between the fourth and fifth wave never returned to the low levels we saw between other waves, “we could technically even argue that South Africa is still in the fourth wave”, says Groome.

The pace at which new infections, hospitalisations and deaths have been increasing during the current surge is also much slower than the rate at which they increased during the initial Omicron (BA.1) surge.

#### Which Covid-19 numbers are now meaningful?

Moreover, says Groome, case numbers have become less meaningful - using them to calculate a wave, even more so: “Severe outcomes like hospitalisations and deaths are better metrics to use now that we have seen the decoupling of cases and severe outcomes.”

Decoupling means that a smaller proportion of new cases now fall very ill with Covid or die of the disease than in pre-Omicron waves.

A Nature study published in April, for example, found people infected with Omicron havea two to five-fold lower risk of dying than people infected with the Delta variant.

Studies show this is because of a combination of changes in the SARS-CoV-2 virus that makes Omicron less able to spread to lungs and, most importantly, increased immunity from vaccination and previous infection.

So what we now want to keep track of is whether - and when - new infections will put strain on our health system because of hospital admissions, rather than how many new Covid cases we have.

“The purpose of calculating the beginning and end of previous waves with case numbers was to adjust public health measures [lockdown policies such as curfews, liquor sales bans and the closing down of schools] accordingly,” explains Groome.

“But increases in cases alone will no longer lead to public health interventions, so we now need to redefine what we consider to be a wave and how we act on that information.”

If Covid-19 now kills smaller proportions of infected people, why still bother with it?

Some people argue, what’s the point of trying to prevent new infections if everyone’s going to get infected anyway? They say, let’s let the virus spread and do little or nothing about it.

But 9 557 people in South Africa died of Covid-19 between 1 January 2022 and 15 May (almost all cases were Omicron infections) - and these are only the reported cases.

The South African Medical Research Council (SAMRC) estimates that at least 85% of excess deaths in the country can also be attributed to Covid.

Excess deaths is a figure that tells researchers how many more people died in a certain period of time than those expected.This figure includes the health department’s Covid death count, and the extra unexpected deaths reported to home affairs’ population register.

The SAMRC uses the date the person died, not when the death was officially recorded. They also balance the figures to account for those who may not end up on the register or who don’t have a South African ID number.

Since the start of the pandemic, the SAMRC and University of Cape Town researchers tallied 311 066 excess deaths. The researchers estimate that between 85% and 95% of excess deaths is likely the real Covid death count (so between 264 000 and 295 512).

Compare just the official death count so far this year  to other respiratory infections such as the flu. According to the NICD, flu kills between 6 000 and 11 000 people per year in the country. Covid caused 62 258 reported deaths in 2021 - more than five times higher than flu deaths (when using the upper range of flu casualties).

Say the flu only causes 6 000 deaths in a year, Covid deaths were still 10 times more than flu deaths in 2021 (during 2021, both the Delta and Omicron variants were in circulation).

New Covid treatments are becoming available to lower the chance of severe disease and death in infected people - but these treatments are expensive, for now, mostly only available in high-income countries.

In the absence of these Covid treatments, the best ways to reduce your risk of falling very ill with Covid-19 is to either not get infected or to develop immunity from getting vaccinated, naturally infected, or both.

But dying or getting hospitalised are not the only Covid-related risks - research shows Covid can can cause long-term heart (cardiovascular), brain (neurological) or hormonal (endocrine) effects.

Scientists in the United Kingdom took scans of people’s brains before and after they were infected with SARS-CoV-2, and found alarming results.

People who caught the bug showed signs of brain damage in a number of regions of the brain, including sections that play a role in memory and smell. This was true even for people who had mild forms of Covid.

Says Abdool Karim: “We should be trying to prevent and/or slow the spread of infection as every person who does not get infected is saved from the risk of not only acute infection consequences but its many long-term consequences.”

One of the longer-term consequences is long Covid.

International studies have shown that long Covid could affect between 25% and 35% of people who were infected with SARS-CoV-2.

The illness has a list of over 50 debilitating symptoms such as persistent headaches, fatigue, hair loss, shortness of breath and attention disorder, that can show up months after someone has recovered from SARS-CoV-2 infection.

That’s the case even if that person was infected but didn’t show any symptoms.

Recent studies have shown that even people who had no visible symptoms when they got infected with SARS-CoV-2, can develop long Covid.

Most people with long Covid just don’t recover after they get sick initially, says Resia Pretorius, the head of Stellenbosch University’s department of physiology. “Instead, their symptoms ebb and flow, but never fully disappear.”

*Update 19 May 2022: A previous version of this story added the health department's death count to excess deaths, which resulted in a double count since the SAMRC’s statistics already account for officially reported figures. An paragraph was added to explain how excess death is calculated.