Western Cape police seized drugs worth around R5.5 million in a bust in Namaqualand, along the Cape's west coast.
It is understood that the drugs were destined for Cape Town.
Narcotics detectives in Vredendal followed a tip-off that a vehicle was transporting drugs in the area on Monday afternoon.
The vehicle was pulled over and, upon searching it, officers found a hidden compartment that contained the drugs.
Police found 8.98 kilogrammes of crystal meth, 2.08 kilogrammes of heroin and 3.26 kilogrammes of cocaine, police spokesperson Brigadier Novela Potelwa said.
"The monetary value of the consignment is estimated at R5.5 million," she added.
Two men, aged 39 and 32, have been arrested, as well as a 33-year-old woman. They face charges of dealing in drugs and possession of drugs and are expected to appear in the Klawer Magistrate's Court on Wednesday.
The bust follows a massive raid on the west coast in March in which officers seized a R583 million cocaine shipment.
In the operation, led by the Western Cape Organised Crime Narcotics Unit, officers descended on a shipping vessel off the coast of Saldanha.
They found 973 blocks of compressed cocaine with an estimated value of R583 million in three compartments of the vessel.
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