Of the 181 Covid-19 cases in the Western Cape as of 09:00 on Thursday, the City of Cape Town has recorded the vast majority with 152.
The Cape Winelands recorded 10 cases (one more since Wednesday); the Overberg has six (one more since Wednesday), the Garden Route 12 (no increase); and one was listed as "unknown".
Western Cape Premier Alan Winde said three residents have been admitted to hospital due to Covid-19.
He added these were only the recorded cases and many more could be infected without knowing.
"I want to confirm that these are only confirmed laboratory cases. There are likely many more people who have the virus and who are not yet showing symptoms. That is why this lockdown is so important, and why staying home is our strongest weapon against it."
Winde said teams of up 100 people were working tirelessly to trace contacts who needed to be tested.
Amid the rapid spread of the virus and the looming national lockdown, the premier called on residents to obey the upcoming lockdown, set to begin on Thursday, by staying at home.
"If we all do this, we will be able to go back to our lives again and start to rebuild our economy. If we do not, and the virus continues to spread, many people will die, and the lockdown may be extended."
On Wednesday, Winde said the Western Cape was seeking to procure medical supplies on an urgent basis.
"The WCG [Western Cape government] coronavirus health work stream is urgently addressing the need for various medical supplies, some of which are already en route.
"The province has placed orders of R45 million in medical equipment and personal protective equipment."
The provincial cabinet was also ensuring a co-ordinated approach to the coronavirus, Winde said.
"Four of the province's six districts have confirmed Covid-19 infections.
"Residents can be assured that district municipalities will also continue to render all essential services, including firefighting, road maintenance and environmental health services, over the lockdown period."
Winde also welcomed the creation of coronavirus pamphlets written in Braille to help spread important messages.