Rarely do lions take on buffaloes no matter how skillful they are at hunting. Except if there is an ailing one, often isolated for reasons of age or chased out of the herd by young dominant bulls. Then the lions might take a chance.
Such a bull, often referred to as a "daka boy", because of the mud on its body, stays near a dam or drainage with water and lush grass. Its only friends being the ox peckers that feeds on ticks on its body.