Gqeberha police were alerted to the bullet-riddled body of a man in Walmer Township on Wednesday.
Police spokesperson Colonel Priscila Naidu said the discovery was made after police responded to a shooting incident at about 13:00.
Naidu said that, on arrival, police found the body of a 36-year-old male in an alley between Goniwe Street and Area Q.
"He sustained multiple gunshot wounds," said Naidu.
A case of murder was opened for investigation.
Naidu said the identity of the deceased person has been withheld until his next of kin is traced.
The man's lifeless body was discovered just hours after two men were shot and killed outside a shopping mall on Heugh Road at 11.30 the same day.