Cape Town - The Proteas will bowl first in the third and final ODI of the series against England at Lord's on Monday.
Captain AB de Villiers won the toss for the third time in the series and, for the third time, opted to chase.
Regardless of the result, South Africa cannot win the series after England won the first ODI in Leeds by 72 runs and then the second ODI in Southampton by two runs.
South Africa have brought in fast bowler Morne Morkel while Wayne Parnell and JP Duminy also return.
England, meanwhile, have rested Ben Stokes, Moeen Ali and Chris Woakes for the clash while Toby Roland-Jones comes in for his debut.
Alex Hales, Jason Roy, Joe Root, Eoin Morgan (captain), Jonny Bairstow, Jos Buttler (wkt), Adil Rashid, David Willy, Toby Roland-Jones, Jake Ball, Steven Finn
Quinton de Kock (wkt), Hashim Amla, Faf du Plessis, AB de Villiers (captain), JP Duminy, David Miller, Chris Morris, Wayne Parnell, Kagiso Rabada, Keshav Maharaj, Morne Morkel