England's Jofra Archer, Ben Stokes and Sam Curran will be rested from the one-day international leg of the 50-over world champions' tour of South Africa, it was announced on Tuesday.
But with the 2021 T20 World Cup on the horizon, the three players were all included in the squad for the three Twenty20s, which start later this month, ahead of the three-match ODI series.
Players will be confined to bio-secure bubbles during the tour as they were during the English international season.
Archer, Stokes and Curran have all been in a new bubble while taking part in the Indian Premier League tournament, which is being staged in the United Arab Emirates due to the coronavirus.
Fast bowler Archer, a hero of last year's World Cup final win, spent 87 days in the England bubble.
Star all-rounder Stokes missed a chunk of the English season to spend time with his ill father in New Zealand but left-arm seamer Curran appeared in both red and white-ball internationals.
England national selector Ed Smith, defending the decision to rest the trio, pointed out how the side's improved white-ball form had coincided with more players being allowed to participate in the IPL.
"If you look at the commitment shown to England by those three players -- Curran, Archer and Stokes -- and their big performances in an England shirt, I don't think anyone could question their commitment to the cause," Smith said.
"Clearly multi-format players, who also play franchise cricket, so the players we're talking about -- (Jos) Buttler, Stokes, Archer and Curran -- are people who need some rest and we, as selectors, are very mindful of that.
"We're going to take those opportunities to give them a break when we believe it's in England's best interests and that's what we're doing for the second leg of this South Africa tour."
Smith said Covid-19 protocols had changed the concept of rest.
"It's that awareness of whether players are feeling really depleted by the experience or in some cases they are feeling comfortable and they are travelling well," he added.
"They are the conversations that are going to be very important in terms of England's performance."
Archer, speaking last week, said he was counting down the days until he was "free again" after spending so much of the past few months in a bubble.
Reece Topley, whose career has been blighted by injury, is in both 15-man squads, with fellow left-arm quick David Willey ruled out by a back problem.
Warwickshire paceman Olly Stone, Lancashire batsman Liam Livingstone and Somerset all-rounder Lewis Gregory have a chance to impress during the ODIs in the absence of Stokes, Archer and Curran.
But England Test captain Joe Root and fellow World Cup-winner Chris Woakes were both left out of the T20 squad.
England's matches in South Africa will be staged at Boland Park in Paarl and Newlands, in Cape Town.
Newlands will stage both the opening T20 on 20 November and the first ODI on 4 December.
T20I squad: Eoin Morgan (Middlesex, captain), Moeen Ali (Worcestershire), Jofra Archer (Sussex), Jonny Bairstow (Yorkshire), Sam Billings (Kent), Jos Buttler (Lancashire), Sam Curran (Surrey), Tom Curran (Surrey), Chris Jordan (Sussex), Dawid Malan (Yorkshire), Adil Rashid (Yorkshire), Jason Roy (Surrey), Ben Stokes (Durham), Reece Topley (Surrey), Mark Wood (Durham).
ODI squad: Eoin Morgan (Middlesex, captain), Moeen Ali (Worcestershire), Jonny Bairstow (Yorkshire), Sam Billings (Kent), Jos Buttler (Lancashire), Tom Curran (Surrey), Lewis Gregory (Somerset), Liam Livingstone (Lancashire), Adil Rashid (Yorkshire), Joe Root (Yorkshire), Jason Roy (Surrey), Olly Stone (Warwickshire), Reece Topley (Surrey), Chris Woakes (Warwickshire), Mark Wood (Durham).
27 Nov: South Africa v England, 1st T20, Newlands, Cape Town
29 Nov: South Africa v England, 2nd T20, Boland Park, Paarl
1 Dec: South Africa v England, 3rd T20, Newlands, Cape Town
4 Dec: South Africa v England, 1st ODI, Newlands, Cape Town
6 Dec: South Africa v England, 2nd ODI, Boland Park, Paarl
9 Dec: South Africa v England, 3rd ODI, Newlands, Cape Town