Cardiff - Wales flyhalf Owen Williams has been ruled out of the rest of the Six Nations with a hamstring injury, the Welsh Rugby Union (WRU) announced on Tuesday.
The 27-year-old Gloucester playmaker has had a miserable run with fitness problems, only returning in January after nine months out with a knee issue.
Williams - who can also play inside centre - injured his hamstring in the warm-up prior to Saturday's 24-14 defeat by Ireland in Dublin.
He was in the squad as a back-up to first choice Dan Biggar but Jarrod Evans came in for him on the replacements bench and replaced Biggar when he went off due to a clash of heads.
"Further assessment has concluded that the injury will rule Williams out of the remainder of Wales' Six Nations Campaign," read the WRU statement.
The three-times capped Williams's injury will be a blow to his club too as they lost first choice outside-half Danny Cipriani for two months in mid-January due to a torn calf muscle.