Griquas have beaten the Lions 41-31 at Ellis Park, where winger Eduan Keyter scored four tries in a Currie Cup encounter that produced nine tries.
Griquas sprinted out the blocks, with flank Gideon van der Merwe opening the scoring in the 1st minute.
Flyhalf George Whitehead added the conversion and added a penalty in the 22nd minute for a 10-0 lead.
After a period of pressure, the Lions were on the scoreboard in the 30th minute thanks to quick thinking by scrumhalf Morne van den Berg.
He caught Griquas napping by taking a quick tap penalty and dashing over the line for an unconverted try.
The Lions then took the lead in the 33rd minute with prop Sti Sithole crashing over under the uprights from close range.
Flyhalf Jordan Hendrikse converted to give the home franchise a 12-10 lead.
Griquas hit back almost immediately as Keyter beat a couple of defenders to score in the 36th minute.
Whitehead converted as the visitors led 17-12 going into the break.
The Lions started the second half with possession and territorial dominance.
They made that count in the 46th minute as winger Rabz Maxwane scored after some quick hands by the backline.
Hendrikse slotted the conversion from a tight angle to put the home side back into a 19-17 lead.
But Griquas were back in the lead just five minutes later as a Whitehead penalty moved the score out to 20-19.
The defining moment in the clash came a few minutes later when the Lions then lost fullback EW Viljoen to a red card for a dangerous tackle that resulted in contact to the head of a Griquas player.
That left the home side down to 14 men with 27 minutes left in the contest.
Griquas put the extra man to good use almost immediately as Keyter collected a cross-kick to score unopposed in the left hand corner.
Whitehead added the conversion as Griquas extended their lead to 27-19.
The home side, however, weren't done yet and after multiple penalties thanks to their scrum dominance, they worked their way into the Griquas 22 metre area.
After numerous attempts at the Griquas line, prop Ruan Dreyer eventually forced his way over.
Hendrikse converted and the 14-man Lions were just a point of Griquas with the score at 27-26 in the 64th minute.
Griquas, however, again found space acres of space thanks to their extra man and Keyter cantered over for his hat-trick try in the 67th minute.
Whitehead added the conversion from the touchline as Griquas moved out to a 34-26 lead with 12 minutes left in the encounter.
It was like deja vu in the 69th minute as that man Keyter scored his fourth try of the match, again after receiving the ball in acres of space on the left hand side of the field.
Whitehead added the extras for Griquas to lead 41-26.
The Lions were down to 13 men in the 74th minute as replacement Duncan Matthews was sent to the sin bin for 10 minutes for dangerous play.
Replacement Travis Gordon brought some respectability to the score in the 79th minute with an unconverted try for the Lions that made the score 41-31.
That's the way it stayed until the hooter as both sides managed to secure a bonus point for scoring four tries or more.
The Lions next match is against away to the Bulls on 25 July, while Griquas are also away to the Sharks a week later on 31 July.
Tries: Morne van den Berg, Sti Sihole, Rabz Maxwane, Ruan Dreyer, Travis Gordon
Conversions: Jordan Henrdikse (3)
Tries: Gideon van der Merwe. Eduan Keyter (4)
Conversions: George Whitehead (5)
Penalties: George Whitehead (2)
15 EW Viljoen, 14 Stean Pienaar, 13 Manuel Rass, 12 Burger Odendaal, 11 Rabz Maxwane, 10 Jordan Hendrikse, 9 Morne van den Berg, 8 Francke Horn (captain), 7 Sibusiso Sangweni, 6 MJ Pelser, 5 Reinhardt Nothnagel, 4 Ruben Schoeman, 3 Jannie du Plessis, 2 Jaco Visagie, 1 Sti Sithole
Substitutes: 16 PJ Botha, 17 Ruan Dreyer, 18 Carlu Sadie, 19 FP Pelser, 20 Travis Gordon, 21 Andre Warner, 22 Fred Zeilinga, 23 Duncan Matthews
15 Ashlon Davids, 14 Daniel Kasende, 13 Jay Cee Nel, 12 Johnathan Francke, 11 Eduan Keyter, 10 George Whitehead, 9 Stefan Ungerer, 8 Ruan Steenkamp (captain), 7 Hanru Sirgel, 6 Gideon van der Merwe, 5 Cameron Lindsay, 4 Adre Smith, 3 Janu Botha, 2 Janco Uys, 1 Mox Mxoli
Substitutes (from): 16 HJ Luus, 17 Andrew Beerwinkel, 18 Andries Schutte, 19 Mzwanele Zito, 20 Sibabalo Qom, 21 Raegan Oranje, 22 Tinus de Beer, 23 Ederies Arendse, 24 Andrew Kuhn, 25 Jeandre Leonard, 26 Theo Boshoff