Pretoria - Wiehahn Herbst will start at prop and flank Marco van Staden will play off the bench when the Blue Bulls take on the Free State Cheetahs at Loftus Versfeld on Friday.
Both players will make a first appearance in the 2019 Currie Cup.
Herbst was a late withdrawal and missed the opening match against Western Province last week due to the birth of his child, while Van Staden was part of the Springbok squad preparing for the Rugby Championship match against Australia and has been released for this clash.
Herbst takes over from Conraad van Vuuren and Van Staden takes Roelof Smit's place on the bench.
Smit will start the match in place of injured Wian Vosloo.
Lock Andries Ferreira will also make a first start for the Blue Bulls against his former province, replacing Lood de Jager, who has been recalled to the Springbok squad to face the Wallabies.
Human said the team will have the opportunity to not only redeem themselves following last weekend's 20-5 defeat to Western Province, but can do so in front of the Loftus faithful.
"We need to be at our best. The Free State Cheetahs will be well-rested and have some really good players available. They will be very keen to get their season started. We have to start well, keep playing well and finish well in this one. We created some chances last week, but with some of our phases not functioning as it should have, we never really managed to force dominance. That needs to change this weekend," said Human.
Blue Bulls captain, Burger Odendaal, said the focus will be on themselves, rather than the opponents.
"We spoke about the errors made last weekend and how to make them right. We all agreed on how to do that, so it is now a matter of going out there and execute the type of game we know we can play."
Kick-off is at 19:15 on Friday.
The referee for the clash is Marius van der Westhuizen.
15 Divan Rossouw, 14 Cornal Hendricks, 13 Johnny Kotze, 12 Burger Odendaal (captain), 11 Rosko Specman, 10 Manie Libbok, 9 Embrose Papier, 8 Tim Agaba, 7 Roelof Smit, 6 Ruan Steenkamp, 5 Andries Ferreira, 4 Ruan Nortje, 3 Wiehahn Herbst, 2 Jaco Visagie, 1 Simphiwe Matanzima
Substitutes: 16 Johan Grobbelaar, 17 Dayan van der Westhuizen, 18 Conraad van Vuuren, 19 Jean Droste, 20 Marco van Staden, 21 Ivan van Zyl, 22 Marnitz Boshoff, 23 Dylan Sage
Free State Cheetahs
15 Louis Fouche, 14 William Small-Smith, 13 Benhard Janse van
Rensburg, 12 Dries Swanepoel,11 Rabz Maxwane, 10 Tian Schoeman, 9 Tian
Meyer (captain), 8 Henco Venter, 7 Abongile Nonkontwana, 6 Junior
Pokomela, 5 Walt Steenkamp, 4 Sintu Majezi, 3 Aranos Coetzee, 2 Joseph
Dweba, 1 Ox Nche
Substitutes: 16 Jacques du Toit, 17 Charles Marais, 18 Reinach Venter, 19 JP du Preez, 20 Jasper Wiese, 21 Gerhard Olivier, 22 Dian Badenhorst, 23 Darren Adonis