The Springboks are preparing to field a team made up exclusively of locally-based when they tackle England at Twickenham on 26 November.
According to Rapport, only SA-based players will be considered for the match as it falls outside of World Rugby's official Test window.
The Boks will likely be without a host of overseas-based stars for the match unless prior arrangements are made with their clubs.
The players affected include Malcolm Marx, Joseph Dweba, Trevor Nyakane, Vincent Koch, RG Snyman, Lood de Jager, Eben Etzebeth, Franco Mostert, Pieter-Steph du Toit, Rynhardt Elstadt, Jean-Luc du Preez, Dan du Preez, Kwagga Smith, Marco van Staden, Jasper Wiese, Duane Vermeulen, Faf de Klerk, Cobus Reinach, Handre Pollard, Elton Jantjies, Damian de Allende, Cheslin Kolbe, Jesse Kriel and Willie le Roux.
The report in the Afrikaans newspaper added that that three other Springbok Tests in 2022 have been earmarked for locally-based players.
Those matches are likely to be the third home Test against Wales on 23 July - provided the Boks win the first two Tests in the series - and the Rugby Championship encounter against Argentina on 24 August.
On their year-end tour, the world champions are also scheduled to play Ireland, France and Italy, with the match against the Azzurri likely to be used to field the SA-based players.
The topic of whether overseas players should be picked by the Boks was recently re-ignited by Bulls director of rugby Jake White, who told SA Rugbymag that the time was right to invest in local players.
"Now is a good time, before the next contracting cycle, for SA Rugby to draw a line on picking players who are contracted to overseas clubs," the former Springbok mentor said.
"South Africa are world champions and SA Rugby did something that has worked because, in 2018 when Rassie Erasmus was appointed, the current cycle of Springbok players were all overseas. But we can't allow that with the next cycle of players."