London - Billy Vunipola will miss England's autumn Test campaign after breaking his left arm, Premiership club Saracens confirmed on Monday.
The Saracens number eight suffered his latest injury in Sunday's 13-3 Champions Cup win at Glasgow and will undergo surgery on Tuesday.
England boss Eddie Jones has further headaches - Vunipola's brother, prop Mako Vunipola, has a calf strain, and lock Nick Isiekwe has an ankle sprain.
"Nick Isiekwe, Billy Vunipola and Mako Vunipola are set for a spell on the sidelines," Saracens said in a statement.
"The trio were all forced off in Saracens' Heineken Champions Cup win over Glasgow Warriors on Sunday.
"Isiekwe suffered an ankle sprain and is waiting to be assessed by a consultant with regards to the full extent of the injury.
"Billy has fractured his left arm and will have surgery on Tuesday. He is expected to be out of action for around 12 weeks.
"Mako picked up a calf strain and his progress will be monitored."
England play South Africa on November 3 with matches against New Zealand, Japan and Australia to follow.