Brisbane - Star forward David Pocock will miss the remainder of the Test series against England after suffering a fractured eye socket during Saturday's 39-28 loss in Brisbane, the Australian Rugby Union confirmed.
Number eight Pocock, rated one of world rugby's best players, was replaced in the 69th minute of the first Test under the blood rule before scans later confirmed the injury.
Pocock, 28, has missed just one Test through injury since 2014, following a knee reconstruction.
Wallabies head coach Michael Cheika has so far not confirmed a replacement, with Western Force number eight Ben McCalman and Waratahs' Wycliff Palu already both part of Australia's extended squad.
Australia must win the second Test in Melbourne next Saturday to keep the three-Test series alive.
England's win over the second-ranked Wallabies was their first in Brisbane and only their fourth victory in 18 internationals between the two nations in Australia.