Cape Town - Bafana Bafana head coach Stuart Baxter has called up two new players as late replacements for the inured duo of Thapelo Morena and Vincent Pule.
Cape Town City defender Thamsanqa Mkhize has been called up as cover for the injured Morena while Orlando Pirates attacker Thembinkosi Lorch replaces Vincent Pule.
Morena pulled up with an injury in the pre-match warm-up just before his side's Absa Premiership clash against Bidvest Wits on Sunday.
Baxter had revealed to journalists that both players were to undergo scan to reveal the extent of their injuries with both players now confirmed to be ruled out.
Bafana Bafana welcome Seychelles to the FNB Stadium on October 13 before a return-leg on October 16.
Kick-off is at 15:00.
FULL BAFANA BAFANA SQUAD:
Itumeleng Khune (Kaizer Chiefs), Ronwen Williams (SuperSport United), Darren Keet (Wits)
Ramahlwe Mphahlele (Kaizer Chiefs), Motjeka Madisha (Mamelodi Sundowns), Thamsanqa Mkhize (Cape Town City), Siyanda Xulu (Maritzburg United), Innocent Maela (Orlando Pirates), Thulani Hlatshwayo, S'Fiso Hlanti, Buhle Mkhwanazi (all Wits)
Aubrey Modiba, Dean Furman, Teboho Mokoena (both SuperSport United), Hlompho Kekana, Sibusiso Vilakazi, Lebogang Maboe (all Mamelodi Sundowns), Thabo Nodada (Cape Town City), Kamohelo Mokotjo (Brentford, England), Thembinkosi Lorch (Orlando Pirates)
Lebogang Phiri (Guingamp, France), Dino Ndlovu (Hangzhou, China), Percy Tau (Royal Union, Belgium), Lebo Mothiba (Strasbourg, France), Phakamani Mahlambi (Mamelodi Sundowns)