Lille - Paris Saint-Germain were drawn with second-division outfit Orleans in the last 16 as they look towards a sixth consecutive French League Cup trophy.
PSG have won the last five editions of the competition as well as five of the last six Ligue 1 titles.
Thomas Tuchel's top-flight leaders have won all 13 of their league fixtures so far and will be expected to prevail at Orleans' Stade de la Source on December 18/19.
Elsewhere in the draw PSG's southern rivals Marseille host Strasbourg, Guingamp are at Nice, Thierry Henry's Monaco drew second-division Lorient and Rennes host Nantes in another Ligue 1 pairing.
Second-division Le Havre have the chance of causing an upset when they host the winner of the Nimes v Saint-Etienne tie on November 27, while Amiens host Lyon and Bordeaux are at Dijon.
French League Cup last 16 draw:
Marseille v Strasbourg, Nice v Guingamp, Monaco v Lorient (D2), Rennes V Nantes, Orleans (D2) V Paris Saint-Germain, Le Havre (D2) v Nimes/Saint-Etienne, Amiens v Lyon, Dijon v Bordeaux