South African tennis ace Kevin Anderson lost his third round match to Russian Karen Khachanov at the Great Ocean Road Open ATP event in Melbourne on Friday.
Khachanov, the second seed, beat Anderson 6-3, 7-6 (7/5) to advance to the quarter-finals.
The event is one of two ATP 250-level tournaments currently being played in Melbourne as preparation for next week's Australian Open.
It was Anderson's second ATP Tour match against world No 20 Khachanov, with the South African having won their previous encounter 4-6, 6-2, 6-3 at the Miami Masters in 2018.
Anderson, the current world No 82, had notched two wins earlier in the week, beating Spanish veteran Feliciano Lopez 6-4, 7-5 and German world No 128 Cedrik-Marcel Stebe 6-4, 6-2.
Meanwhile at the other ATP 250 event, the Murray River Open, Anderson's compatriot Lloyd Harris bowed out in the first round on Monday when he lost to Belarusian Egor Gerasimov in straight sets, 6-3, 7-5.
Harris and Anderson will now shift their focus to the year's first Grand Slam starting at Melbourne Park next Monday (8 February).
Anderson faces Italian ninth seed Mateo Berrettini in the first round, while Harris will open his account against unseeded Mikael Torpegaard from Denmark.
Collated results on Friday from the ATP Murray River Open and Great Ocean Road Open at Melbourne Park:
Murray River Open
Stan Wawrinka (SUI x1) bt Alex Bolt (AUS) 6-4, 4-6, 7-6 (7/5)
Jeremy Chardy (FRA) bt Taylor Fritz (USA x6) 6-2, 6-4
Borna Coric (CRO x4) bt Nick Kyrgios (AUS x13) 6-3, 6-4
Daniel Evans (GBR x8) bt Marcos Giron (USA) 6-4, 7-6 (7/4)
Jiri Vesely (CZE) bt Ricardas Berankis (LTU) 6-4, 6-2
Félix Auger-Aliassime (CAN x3) bt Egor Gerasimov (BLR) 3-6, 6-3, 7-6 (8/6)
Corentin Moutet (FRA) bt James Duckworth (AUS) 7-6 (7/4), 6-4
Grigor Dimitrov (BUL x2) bt Alexei Popyrin (AUS) 6-4, 6-7 (5/7), 6-3
Jeremy Chardy (FRA) bt Stan Wawrinka (SUI x1) retired
Daniel Evans (GBR x8) bt Borna Coric (CRO x4) 7-5, 7-6 (7/1)
Felix Auger-Aliassime (CAN x3) bt Jiri Vesely (CZE) 7-6 (7/3), 0-0 abandon
Corentin Moutet (FRA) bt Grigor Dimitrov (BUL x2) 7-5, 6-2
Great Ocean Road Open
Thiago Monteiro (BRA) bt Carlos Alcaraz (ESP) 7-6 (7/3), 6-3
Jordan Thompson (AUS x11) bt Mario Vilella (ESP) 6-4, 6-4
Hubert Hurkacz (POL x3) bt Pablo Cuevas (URU) 7-5, 7-5
Stefano Travaglia (ITA) bt Alexander Bublik (KAZ x8) 6-1, 7-5
Miomir Kecmanovic (SRB x7) bt Salvatore Caruso (ITA) 7-6 (7/5), 5-7, 7-5
Jannik Sinner (ITA x4) bt Aljaz Bedene (SLO x13) 7-6 (8/6), 6-2
Botic van de Zandschulp (NED) bt Reilly Opelka (USA x6) 7-6 (8/6), 7-6 (7/4)
Karen Khachanov (RUS x2) bt Kevin Anderson (RSA) 6-3, 7-6 (7/5)
Thiago Monteiro (BRA) bt Jordan Thompson (AUS x11) 6-4, 6-4
Stefano Travaglia (ITA) bt Hubert Hurkacz (POL x3) 3-6, 6-3, 7-5
Jannik Sinner (ITA x4) bt Miomir Kecmanovic (SRB x7) 7-6 (12/10), 6-4
Karen Khachanov (RUS x2) bt Botic van de Zandschulp (NED) 6-7 (6/8), 7-5, 6-3