A Proteas side with no less than seven changes will field first in the third and final ODI against Pakistan at SuperSport Park on Wednesday.
LIVE | Proteas v Pakistan - 3rd ODI
This comes after captain Temba Bavuma won the toss in the series decider.
South Africa lost five players - Quinton de Kock, David Miller, Kagiso Rabada, Lungi Ngidi and Anrich Nortje - to the IPL this week while, on Wednesday morning, it was confirmed that Rassie van der Dussen had been ruled out with injury.
Janneman Malan and Kyle Verreynne have come in for De Kock and Miller, respectively, while JJ Smuts is included to replace Van der Dussen.
In the fast bowling department, there are call-ups for Beuran Hendricks, Lutho Sipamla and Daryn Dupavillon.
The final change is rotational with spinner Keshav Maharaj replacing Tabraiz Shamsi.
Play starts at 10:00
Aiden Markram, Janneman Malan, Temba Bavuma (captain), JJ Smuts, Kyle Verreynne, Heinrich Klaasen, Andile Phehlukwayo, Keshav Maharaj, Daryn Dupavillon, Beuran Hendricks, Lutho Sipamla
Fakhar Zaman, Imam-ul-Haq, Babar Azam (captain), Mohammad Rizwan, Sarfraz Ahmed, Muhammad Nawaz, Faheem Ashraf, Hassan Ali, Shaheen Shah Afridi, Usman Qadir, Haris Rauf