Pakistan captain Babar Azam has won the toss and asked South Africa to bat first in the final T20 International at SuperSport in Centurion on Friday.
The Proteas have made two changes, with all-rounder Wiaan Mulder handed his T20I debut and slow left-armer Bjorn Fortuin also coming into the side.
Beuran Hendricks and Pite van Biljon are the players missing out.
Pakistan, who lead the series 2-1, are unchanged.
Play starts at 14:30.
Aiden Markram, Janneman Malan, Rassie van der Dussen, Heinrich Klaasen (captain, wicketkeeper), George Linde, Andile Phehlukwayo, Wiaan Mulder, Sisanda Magala, Bjorn Fortuin, Lizaad Williams, Tabraiz Shamsi
Mohammad Rizwan (wicketkeeper), Babar Azam, Fakhar Zaman, Mohammed Hafeez, Haider Ali, Asif Ali, Faheem Ashraf, Mohammad Nawaz, Hassan Ali, Shaheen Afridi, Haris Rauf
Umpires: Shaun George, Adrian Holdstock (both RSA)
Television umpire: Allahudien Paleker (RSA)
Match referee: Andy Pycroft (ZIM)