Our referee is Jonathan Moss. He will be assisted by Marc Perry and Dan Robathan. The fourth official is Graham Scott and the VAR is Martin Atkinson.
Manchester United: De Gea, Wan-Bissaka, Lindelof, Maguire, Telles, Matic, Fred, Fernandes, Van de Beek, Rashford, Greenwood.
Subs: Henderson, Cavani, Mata, James, Fosu-Mensah, Williams, Tuanzebe.
Southampton: McCarthy, Walker-Peters, Vestergaard, Bednarek, Bertrand, Romeu, Ward-Prowse, Walcott, Armstrong, Djenepo, Adams.
Subs: Forster, Stephens, Long, Obafemi, Tella, Diallo, N’Lundulu.
In their last league outing The Saints had to settle for a 1-1 draw against Wolves, while The Red Devils scraped 1-0 past West Bromwich Albion.
Unfortunately Southampton will be without the injured Danny Ings for this important clash, while Paul Pogba and Scott McTominay will be non-starters for United.
The Saints are currently fifth on the table, while United are in 12th position.
G'Day and welcome to St. Mary's Stadium for our liv e coverage of this English Premiership clash between Southampton and Manchester United.
Kick-off! We are underway here and Southampton get us underway.
Fernandes tries to send Greenwood on his way, but Bertrand is awake and clears.
Great work by Romeu in the right corner to ensure that the ball goes behind off Wan-Bissaka and it's a Southampton goal-kick.
WIDE! A big chance for United after a good pass into space for Greenwood. How did he miss the target from there? Vestergaard just switched off for Southampton there.
NO PENALTY! for United after a collision in the Southampton box between Ward-Prowse and Rashford.
It has been a brisk enterprising start by Manchester United.
Fernandes is down after a good strong tackle by Romeu. A foul is awarded. Strange! The set-piece is cleared.
Rashford combines with Fernandes and fires a long-range shot to hit the POST!
YELLOW! Ward-Prowse is booked for a challenge on Van De Beek.
United are looking sound and have settled the best of the two teams thus far.
Southampton are now awake! Djenepo sends the ball into the area after a good build-up, but Van De Beek does well to clear. They secure a corner.
GOAL, SOUTHAMPTON, BEDNAREK! (1-0) Ward-Prowse curls in the corner and a free Bednarek heads it home. Great work against the run of play!
United are unlucky to be a goal down and Greenwood missed a golden opportunity early on.
POST! Oh so close for Southampton again. Walker-Peters fires towards goal, but a deflection sends it away for a corner. The corner leads to another and then United eventually clear.
SAVE! Southampton survives after a crucial stop by McCarthy after a Greenwood shot. it was a great reaction save and then Fernandes fails to put the rebound away. It started with a keeper error.
GOAL, SOUTHAMPTON, WARD-PROWSE! (2-0) Southampton win a free-kick on the edge of the box and what a brilliant delivery from Ward-Prowse to find the top left corner to beat De Gea, who got a hand to it. WOW!
Djenepo fires a long-range shot and De Gea is called into action. The keeper is down though and was also down after the previous goal.
How quick things change and now The Saints are enjoying a free-flowing game.
De Gea is still not happy. He may just stick it out until the break.
Djenepo runs into space again, but fails to find the killer strike for Southampton before the break.
We will have two minutes of time added on for stoppages.
HALF-TIME: SOUTHAMPTON 2-0 MANCHESTER UNITED. The hosts lead at the break thanks to two brilliant goals. United had a golden opportunity from Greenwood early on that was wasted. Since the first goal it's been all Saints!
Kick-off! We are back underway in the second half.
SUBSTITUTION: A forced change for United after De Gea was injured trying to stop the Ward-Prowse goal. It's a double change at the break, as Cavani is also on for Greenwood. Interesting!
SAVE! Henderson is called into his first save after a strike from Walcott following a Southampton counter-attack.
Lindeloff does well to stop Armstrong after Walcott sends him into space. That's better defending from United.
WHAT A CHANCE! Fernandes fires a shot and McCarthy punches it into the path of Van De Beek. Neither he nor Cavani can put it away.
Bednarek is now down injured after a collision with a fellow player.
GOAL, MANCHESTER UNITED, FERNANDES! (2-1) They strike back! Cavani crosses it into the box and finds Fernandes, who opens his account with a cool strike from in front of goal.
Can United get back into this and get closer to the top of the table?
And suddenly the United machine is on fire again!
Having said that! Bertrand then secures a corner off Wan-Bissaka.
Ward-Prowse swings it in and United clear. Fernandes sends it long and Rashford manages to keep it in play.
United are now getting back into their stride.
SUBSTITUTION: A change for The Saints and Djenepo has been replaced by Long.
GOAL, MANCHESTER UNITED, CAVANI! (2-2) It's all square and United may well go on to win it from here. It was made to look easy, as he snuck in and just glanced it passed the keeper like a poacher!
We will certainly see a goal either way with 15 minutes to go.
The Saints will have to settle quickly or they will come short here.
Henderson does well to watch a shot from Adams go wide of his post! A good move by the home team.
One sense that a United goal is just moments away. Rashford fails to get through a crowded Southampton box and they start again.
SUBSTITUTION: Telles has been replaced by Williams for the final United change.
The Saints secure a free-kick in a good position, but Lindelof clears.
The United counter-attack leads to a corner after Maguire is involved. WHAT?
SUBSTITUTION: Armstrong is on for Diallo, as The Saints make a change.
We are into five minutes of time added on for stoppages.
GOAL, MANCHESTER UNITED, CAVANI! (2-3) Fernandes takes a quick free-kick and Rashford then finds Canavani, who wins the game.
FULL-TIME: SOUTHAMPTON 2-3 MANCHESTER UNITED. What a change Cavani as a substitute made since the break and what a turnaround for Manchester United. Great Work! Thank you for joining us.