Liverpool subs: Kelleher, Thiago, Keita, Henderson, Oxlade-Chamberlain, Diaz, Robertson, Origi, Williams.
Liverpool starting XI: Alisson, Gomez, Konate, Matip, Tsimikas, Milner, Jones, Minamino, Jota, Elliott, Firmino.
Southampton subs: Caballero, Romeu, Long, A. Armstrong, Adams, S. Armstrong, Djenepo, Bednarek, Valery.
Southampton starting XI: McCarthy, Walker-Peters, Lyanco, Stephens, Salisu, Tella, Ward-Prowse, Diallo. Redmond, Broja, Elyounoussi.
Liverpool won the FA Cup on penalties against Chelsea on Saturday to make it two trophies this season. Their last league matches saw a 1-1 draw with Tottenham and a 2-1 win at Aston Villa.
Southampton are in poor form with seven losses in 10 league matches. They lost 3-0 away to Brentford in their last match.
Welcome to live coverage of the EPL match between Southampton and Liverpool, kickoff at 8.45PM UK time at St. Mary's Stadium.
Kickoff! 0-0. We get moving at St. Mary's in this must win match for the Reds.
Liverpool have made a good start with a high ball possession share. Saints are sitting back thus far.
BLOCK! Milner strikes a shot from good approach play. Stephens is the one who got a block on the effort.
Konate is down for Liverpool, a knock to the head. He is okay to keep going.
SAVE! Broja makes a good run into space. He dribbles past Matip but Alisson saves with his legs. It looked like more of a cross than a shot.
GOAL, SOUTHAMPTON! REDMOND, 1-0! The home team score first. Redmond runs clear on the left and shoots home via a deflection. Great strike. Klopp is upset and wanted a freekick earlier in the move. Southampton 1-0 Liverpool.
Nearly a chance for Liverpool. Jota onto a through ball in the area, well cleared by Lyanco.
BLOCK! Saints block two shots in a row. Tsimikas had the second strike, charged down well.
NO GOAL! Firmino heads home a freekick, fine header across goal. Offside was called, correct decision.
Jones takes a shot for Liverpool from the edge of the 18-area. A weak attempt, McCarthy is not tested by it.
Not much going on so far. Southampton holding strong at the back but Liverpool are a threat.
GOAL, LIVERPOOL! MINAMINO, 1-1! The Reds are level. Gomez to Jota to Minamino, he smashes it near post into the top corner past the goalie McCarthy. Southampton 1-1 Liverpool.
SAVE! Jota with a blocked shot then Milner with a strike, parried clear by McCarthy in the Southampton goal.
Liverpool putting the pressure on. Tsimikas cross is blocked then a Milner delivery is well caught by the keeper.
CHANCE! Firmino is alive to a low cross, puts it into an area but Ward-Prowse is tracking to clear over his own crossbar.
The Reds totally on top even with all the changes they made. 71% possession share and nine shots thus far.
WIDE! Cheap giveaway by Saints man Diallo. Firmino pounces, his shot is sent over the bar though.
Saints are camped in their own half. Both Liverpool centre backs are playing in the Southampton half.
A long spell of 'Pool pressure ends with a loose Jones pass. Loads of ball near the Saints box but no final ball just yet.
Half time! 1-1. A good game so far, Liverpool totally on top. Maybe a concern if Gomez can out for the second half. Southampton 1-1 Liverpool.
+2' Gomez down for Liverpool in pain. Ankle injury on the face of it.
The fourth official shows two added minutes.
Sub, Liverpool: Gomez off, Henderson on. Milner to right back.
Kickoff! 1-1. The second stanza is underway.
CHANCE! Tsimikas with great play to cross low, it reaches Jota in the box. He shoots on the turn but just wide of the post.
Foul by Milner on Broja, high foot. Freekick chance for Ward-Prowse, the best around at these.
Block! Ward-Prowse shoots but strikes it into the wall.
WIDE! Liverpool are pushing hard. Firmino finds Elliott but he puts a chip just wide of goal.
The away team are stepping it up now, they want this win. Klopp must be considering bringing on Diaz.
WIDE! It's Jones now to try a shot for Liverpool but he sends it wide from a Firmino pass.
Sub, Liverpool: Elliott off, Origi on.
GOAL, LIVERPOOL! MATIP, 1-2! Tsimikas with the corner, it's half cleared and Matip diverts it into the net. Pinball in the area but Klopp won't care. Southampton 1-2 Liverpool.
Milner is down, he got stamped on by Broja. The veteran should be able to run that off.
Subs, Southampton: Romeu and Stuart Armstrong on, Tella and Diallo go off.
Yellow, Southampton. Stephens goes into the book, he caught Origi.
Liverpool just controlling things now, passing it around to wind down the clock. Southampton look low energy.
Wasteful from Liverpool. Jones with the lovely dribble, passes to Minamino but his pass to Milner forces a poor cross from the right back. Milner gives his teammate a mouthful.
Not much is happening. Southampton don't seem to have belief in coming back.
Sub, Liverpool: Firmino off, Keita on.
Sub, Southampton: Adams on, Broja on.
Origi wins it off Lyanco high up but a foul is given. Not much contact there.
Liverpool are keeping it for fun. No sign of Southampton's famous pressing game.
WIDE! Tsimikas corner from the left, Konate up high but can't keep the header down.
WIDE! Terrible kick by McCarthy. Jones has it on the edge of the 18-area, it deflects wide for a corner.
SAVE! Redmond sees a gap and goes into it for Saints. Powerful shot which Alisson parries and then catches second time of asking.
Full time. 1-2. Liverpool get the win and the title race goes to the final day. Minamino and Matip got the key goals in a deserved win. Southampton 1-2 Liverpool.
+2' More Saints pressure. S. Armstrong with two crosses and Konate is twice there to clear it.
Three minutes time added here.
Southampton are finishing strong. A long spell of ball with crosses coming into the area from Walker-Peters and Salisu. It ends with a corner it seems but a soft freekick given to Liverpool instead.