Sharks speedster Aphelele Fassi will start a match for the first time in four months on Saturday in a Champions Cup clash against Harlequins in London.
The highly-rated 24-year-old has been out with a shoulder injury, though he did get 20 minutes off the bench against Bordeaux in Durban last weekend.
Fassi slots in at fullback, replacing the injured Boeta Chamberlain, while Bongi Mbonambi - also injured - is out for Kerron van Vuuren.
Elsewhere, Curwin Bosch is back at flyhalf, Phepsi Buthelezi comes in for Sikhumbuzo Nothse at No 8 and Thaakir Abrahams starts in place of the suspended Makazole Mapimpi.
The Sharks have already qualified for the round of 16 courtesy of their three straight victories, but a win on Saturday will guarantee a home clash in the next round.
Kick-off is at 15:00.
15 Aphelele Fassi, 14 Marnus Potgieter, 13 Lukhanyo Am, 12 Ben Tapuai, 11 Thaakir Abrahams, 10 Curwin Bosch, 9 Jaden Hendrikse, 8 Phepsi Buthelezi, 7 Vincent Tshituka, 6 Siya Kolisi (c), 5 Gerbrandt Grobler, 4 Eben Etzebeth, 3 Thomas du Toit, 2 Kerron van Vuuren, 1 Ox Nche
Substitutes: 16 Dan Jooste, 17 Ntuthuko Mchunu, 18 Carlu Sadie, 19 Hyron Andrews, 20 Sikhumbuzo Notshe, 21 Grant Williams, 22 Lionel Cronje, 23 Francois Venter