European rugby bosses on Thursday confirmed the pool stage fixtures for the 2022/23 European Champions and Challenge Cups.
United Rugby Championship winners, the Stormers, will open their account on French soil when they take on Clermont Auvergne at the Stade Marcel-Michelin, while the Bulls and the Sharks will be at home against Lyon and Harlequins respectively.
Round 1 action will take place on the weekend of 9/10/11 December.
Stade Rochelais, who won a maiden Champions Cup in May, will launch the defence of their title at Stade Marcel Deflandre against another former tournament winners, Northampton Saints.
Elsewhere, English champions Leicester Tigers will open their campaign against Ospreys in Swansea, and last season's French TOP 14 winners, Montpellier, will also be on the road when they face London Irish, who are making a return to the top flight for the first time since 2012, at Brentford Community Stadium.
Two of the tournament's heavyweights, Munster and Toulouse, will renew rivalries in Round 1 in early December at Thomond Park.
CLICK HERE for the 2022/23 Champions Cup pool stage fixtures
Meanwhile, in the second-tier Challenge Cup, the Lions will make their tournament debut away against English club Worcester Warriors, while the Cheetahs, who will play their two "home" matches at Stadio Lanfranchi in Parma, go head-to-head with Section Paloise at Stade du Hameau in the south-west of France.
CLICK HERE for the 2022/23 EPCR Challenge Cup pool stage fixtures