Eindhoven - Luuk De Jong scored a dramatic late leveller as PSV Eindhoven scraped a 2-2 Champions League draw with 10-man Tottenham Hotspur to leave the English giants' campaign hanging by a thread on Wednesday.
With no points from their opening two Group B fixtures, this was make-or-break for both Spurs and PSV at the Philips Stadion.
A dominant Spurs looked to have the points wrapped up after Kane nodded past Jeroen Zoet for a 55th-minute lead after Lucas Moura had equalised after Hirving Lozano's 30th-minute opener for PSV.
But when Lozano threatened to catch a through ball in the 78th minute, goalkeeper Hugo Lloris came rushing out of his goal and caught the Mexican winger with his knee.
The French World Cup winner was immediately shown a red card, with Spurs manager Mauricio Pocchettino taking off Heung-Min Son for second-choice 'keeper Michel Vorm.
Vorm's first task was to push away a superb free-kick at the base of the post, only to be caught ball-watching when De Jong poked a loose ball past him with three minutes left on the clock.
It saw Spurs locked with PSV on one point in Group B, five points behind Barcelona and Inter Milan, who play later Wednesday.
A fast start saw Tottenham quickly take control and in the 18th minute Kane saw a great header come off post and crossbar following a corner from the right.
PSV midfielder Gaston Pereiro fired just a yard wide of Lloris's upright with a 25-yard free-kick and at the other end Zoet was down quickly to smother when Son skipped past the Spurs defence to fire a low shot on target.
Yet the Londoners were stunned on the half hour when Toby Alderweireld panicked on a backpass from Davinson Sanchez as Lozano applied the pressure.
Despite Alderweireld running back to block, Lozano's effort deflected off the Belgian's boot to send the ball over a rooted Lloris.
Tottenham looked to be back on level terms minutes later when, from a corner, Sanchez fired a rebound from Alderweireld's header past Zoet from inside a packed area.
But somehow the goal was ruled offside. Although Kane was in an offside position, the England striker made no attempt to play the ball.
Spurs made amends almost immediately, Christian Eriksen splitting the PSV defence to set up Kieran Trippier for a crisp cross that Lucas fired first-time past Zoet via a deflection.
Tottenham were thankful moments later when Pereiro dribbled past Alderweireld to prod an effort off Lloris's bar.
But Spurs continued to be the better team.
Zoet came to the rescue to deny Eriksen after he was set up by Trippier and the Dane made amends soon after with a superb delivery that saw Kane nod past Zoet at the back post.
Despite Spurs' dominance, the depleted Londoners were made to pay in the final minutes when De Jong pounced in a packed area to poke past Vorm.